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Our paper is out today in nature! Imagine getting this plot when studying single-cell data of growing bacteria! Could it be the cell cycle?! We found that a gene’s response to its replication reveals gene regulation on a genomic scale. nature.com/articles/s4158… Andrew Pountain

Happy Feb 1st!💞 Join us burst 💥with excitement like a phage in lysis cuz 😁: BBM 2024 is now open for registration! It's the 30th bday of BBM 🎂 🎈 🎉! Where were you in 1994? (I was a newborn with the 🎁 of a microbiome 🦠 😝) bostonbacterial.org/registration/ See you all there!😎

Diversification of division mechanisms in endospore-forming #bacteria revealed by analyses of peptidoglycan synthesis in C. difficile Shailab Shrestha Shen Lab #microbiology nature.com/articles/s4146…

Can’t believe this is out!! This is the culmination of >6yr of work to define the mode of action of the compound C10 in Mtb. There’s a LOT we still don’t know about this remarkable compound, but proud of the work accomplished with @StallingsLab Fredrik Almqvist Gary Patti labs! 😃

It's out! My first PhD paper about the Thioredoxin systems of Clostridia! journals.plos.org/plospathogens/…

My better half's second biggest accomplishment of the past six months 👶🍼 nature.com/articles/s4156…

Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile biorxiv.org/content/10.110…

E. coli division machinery drives cocci development inside host cells biorxiv.org/content/10.110… Amazing imaging, cracking open a new area here by Alaska Pokhrel Bill Söderström with @ariana_costas @Matt_Pittorino here!

Bacillus subtilis uses the SigM signaling pathway to prioritize the use of its lipid carrier for cell wall synthesis PLOS Biology by Ian Roney and David Rudner journals.plos.org/plosbiology/ar…

Following up our Cell Reports paper, an avirulent C. difficle clinical isolate out-competes virulent strains in mice via quickly depleting multiple amino acids, and protects mice from developing colitis!

Excited to share our recent pre-print! The Vibrio cholerae encoded Nezha anti-phage system (SIR2-HerA) restricts virulent vibriophages ICP1, ICP2, and ICP3 by depleting NAD+ (Abi💀). However, an ICP1 isolate can overcome this by encoding putative NAD+ regenerating proteins! ⚡️

So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of Ari Sarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12

It's true, cleaned up my bench today after a memorable 6.5 years in the Michael Baym lab! Very excited to start my own lab next month at the NYSDOH Wadsworth Center doing public health adjacent basic research exploring "exotic" bacteriophages!! #newpi

Happy to share a chapter of my PhD thesis🐣! We review the diversity of the cell envelope in Terrabacteria which tell us a lot about outer membrane biogenesis and the diderm-to-monoderm transition. Thanks to my co-authors Najwa Taib @ChrisBel70 Simonetta Gribaldo nature.com/articles/s4157…

Officially published! I’m happy to share my first-author paper out mBio journals.asm.org/doi/10.1128/mb…

The Bartlett Lab is open for business at the Wadsworth Center! We study pathogens with "unusual" shapes (balls & corkscrews) to find vulnerabilities in their growth plans, and learn how bacterial shape impacts infection. We are hiring... join us! wadsworth.org/research/labor…

The cytoplasm is not necessarily chemically uniform, says Delerue, Updegrove, & @Sylvia_Char. Surface of the developing spore inside the #Bacillus subtilis mother cell is acidic & needs a chaperone to activate MurG (lipid II synthase) pnas.org/doi/epub/10.10…

Excited to share that our paper is now out in ⁦Nature Microbiology! We characterize a positive mechanism for Z ring placement in S. aureus governed by the proteins PcdA/DivIVA, and its implication during infection in a mouse model nature.com/articles/s4156…

We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to methicillin requires S. aureus to utilise an alternative mode of cell division to ensure its survival! Sheffield AFM Group Abimbola_Olulana doi.org/10.1126/scienc…