What happens when you get the hepatitis C cured ? Do you feel entitled to eat more and drink more alcohol ? I always had that feeling with my patients. A recent study confirms this: people tend to become more overweight and drink more alcohol. Clinicians should warn about it.

Good news for patients with MASH: semagluide finally improves histology ! FDA approval is closer. Interestingly, placebo improved histology despite minimal weight loss. Why ? Other changes in lifestyle during the trial ? Alcohol, smoking, exercise.....Intriguing.

What public health measures are effective in decreasing the burden of alcohol-related liver disease ? What new measures should be implemented ? We explain it all in this new article in Nature Reviews Gastroenterology & Hepatology

🚨 Next up in #GIHepFellowshipBootcamp, Management of #AUD‼️ 🍷 🍻 You are seeing a patient in 🏥 with AUD, ✅ out this 📑 to help you deliver the best care❕ ⭐️ Screening, incl #Biomarkers ⭐️ Treatment, incl Medications 💊 🚫 stigmatizing language‼️ journals.lww.com/hepcomm/fullte…

Two key points that we need to remember about the new SLD (Steatotic Liver Disease) nomenclature: 1️⃣ SLD ≠ MASLD — it also includes Alcohol-Related Liver Disease (ALD). 2️⃣ A person with metabolic syndrome + 10 drinks/day has ALD, not MetALD. AASLD EASL Education Asociación Española para el Estudio del Hígado

Congratulations to Prof Devanshi Seth (she/her) who has been selected amongst the next cohort of The WILD Program leaders stepping into Board X Observerships - a unique opportunity designed to build boardroom capability and confidence for women and non-binary leaders in STEM. Science & Technology Australia

#alcoholawareness Attention Obby Khan PC Party of Manitoba Wayne Ewasko Cancer care Manitoba is right, for cancer prevention-'Avoid alcohol! All Manitoban's need to know this,and the Premier, Wab Kinew has a duty to inform and protect public health, and take action to prevent it!🇨🇦

Centenary Institute Prof Devanshi Seth (she/her) The WILD Program Science & Technology Australia #alcoholawareness Thank you Seth Prof Devanshi Seth (she/her) for your leadership, and making a difference! ❤️

My GenomALC cohort contributed to this this multi-national study

My GenomALC cohort contributed to this study: illustrates long-term natural history of #alcohol-related #liver disease and defines the risks of outcomes based on the MELD score across the spectrum of disease. steven masson guruprasad aithal Centenary Institute journals.lww.com/ajg/abstract/9….

CIRROXABAN Study is finally here! 🔬 First DB RCT evaluating rivaroxaban in cirrhosis 💡 Complication-free survival benefit in Child‑Pugh B7 (HR 0.26 [95 % CI 0.07–0.90]). ⚠️ Mild bleeding ↑, but no increase in severe events. 📄 journal-of-hepatology.eu/article/S0168-…

Ramon Bataller EASL Education AASLD Asociación Española para el Estudio del Hígado Fully agree. This table from Mangia & Valenti just published review is complementary with data on efficacy.

New clinical trial results: STEP 11 📄🧪 💊 Semaglutide demonstrates 16% weight loss ⚖️⬇️ in adults in South Korea 🇰🇷 and Thailand 🇹🇭, defined as BMI > 25. 📊 These results have meaningful clinical 🩺 and policy 🏛️ implications for Asian countries, where lower BMI thresholds

Defining Risk in Alcohol-Associated Liver Disease Using the Model for End Stage Liver Disease Parker, et al. 📕 doi.org/10.14309/ajg.0… Prof Devanshi Seth (she/her) Neil Rajoriya Ian Rowe Russell Goodman Esperance Schaefer MD Mayur Brahmania MD John Millie Long Jasmohan Bajaj

📊 How to interpret PEth blood levels for recent alcohol intake? Here’s a concise & practical table to guide you.

I often bring up smoking when discussing patients with alcohol-related cirrhosis in our transplant committee. Why? Because alcohol + tobacco massively increase cancer risk. ➡️ Esophagus ~×7 ➡️ Head & neck ~×4 ➡️ Lung ~×2 This is why abstinence & support matter. ⬇️

So true Ramon Bataller there’s seems to be an extraordinary push for MASLD in literature as well as social media overshadowing #ALD to the point of neglect - grave consequences ahead

#alcoholawareness 2025~ October is breast cancer awareness! BC Cancer message, for British Columbia's women- Reduce your risk of breast cancer, no alcohol is best! This should be a high priority for you to support and take action , BC health minister Josie Osborne 🇨🇦 BC NDP

Excited to see a standalone PRS paper for large-scale Taiwanese cohort in a duo of flagship papers (nature.com/articles/s4158… and nature.com/articles/s4158…). Even more thrilled to see PRSmix+ (via cross-trait integration) yields consistent performance across different target traits!

A new GWAS resource: a pheweb server hosting GWAS results of 100+ EHR phenotypes in >500,000 Han Chinese from the Taiwan Precision Medicine Initiative. pheweb.ibms.sinica.edu.tw Yang, Kwok, Li, Liu, Jong, Lee, et al. Nature 2025 nature.com/articles/s4158…