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Omg, these are SO cute. A need for my growing collection of sciency stickers 😭😍

Some (very shallow and quickly taken) impressions of Paris ✨ First day of the #ImmuneSystemsOfBacteria25 conference done, two more days filled with brilliant science to go!

Talk about timing! Presented our work on how RNA-guided mechanisms evolved at the Immune System of Bacteria symposium Institut Pasteur, since 1887—on the same day our Cell paper dropped!

More impressions of Paris/the conference - 3 days of fantastic science ✨

Traveling home from the absolutely exciting bacterial immunity meeting in Paris 🧬☀️🚅. Many thanks to the organizers and especially local host Aude Bernheim Aude Bernheim + team MDMLab for setting this up!

CRISPR associated filament networks providing antiviral immunity! I am very excited to share our recent work co-led by amazing Christian F. Baca and me. The work is now online in Science Magazine! Science.org/doi/10.1126/sc…

All of Vienna is packed into this arena #clancyvienna

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s4158…

Joel Tan Joel Tan discovers a DNA molecular tripwire that guards against viral infection. New research from the Kranzusch (kranzuschlab.med.harvard.edu) and Jost Marco Jost labs in HMS Micro nature nature.com/articles/s4158…

A census of anti-CRISPR proteins reveals AcrIE9 as an inhibitor of Escherichia coli K12 Type IE CRISPR-Cas system biorxiv.org/content/10.110… #biorxiv_micrbio

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…

We performed a dedicated search of anti-CRISPR proteins targeting the model E. coli Type IE CRISPR-Cas system and revealed AcrIE9 as a potent inhibitor and the most widespread anti-CRISPR protein in enteric bacteria. biorxiv.org/content/10.110…

Out now in Molecular Cell: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA cell.com/molecular-cell… Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein? A 🧵

sciencedirect.com/science/articl… 🧐Merchants of death: 131 (!) claims of phage inhibition of host immune systems inducing host-invoked 'death', all based on IPTG-induced promoter over-production results. Hence, 'death' here is likely not physiologically relevant.

my R01 is cancelled lol meanwhile liz holmes AND the crispr baby guy are raising millions I'm going to become the Joker

Exciting news! Our latest paper is out in Nat. Microbiol. Nature Microbiology We show that a sub-lineage of 7th pandemic V. cholerae has acquired mobile genetic elements packed with phage defense systems—rendering it multi-phage resistant 😳 ..... 1/3 nature.com/articles/s4156…

Widespread and Abundant CRISPR-Cas Systems in the Deep Ocean biorxiv.org/content/10.110… #biorxiv_micrbio

Our latest story is now online nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers to protect against viral infection. Congratulations to all authors, and to the Wiedenheft Lab for a fun and fruitful collaboration! nature.com/articles/s4158…

The lightning (Cas12f-Sigma) does strike twice today.⚡️See below for a thread by our collaborators Leifu Chang describing the massive cryo-EM structure of the RNA-guided transcription initiation complex, featuring Cas12f, Sigma and RNA polymerase: