Thrilled to announce the appointment of Joanne Smith-Farrell and Rick Morgan to the leadership team at Be Bio! businesswire.com/news/home/2021…

In new work led by Allie Greaney, we analyze mutational escape of #SARSCoV2 from monoclonal & polyclonal antibodies in terms of RBD epitope classes (biorxiv.org/content/10.110…). Provides useful framework for conceptualizing effects of individual and combined mutations. (1/n)

Finally, enjoyable part of project was getting to build on nice prior work by Christopher Barnes, Ph.D. The Bjorkman Lab Nussenzweig_LAB Paul Bieniasz Theodora. We’ve read & enjoyed their papers on #SARSCoV2 antibodies, so appreciated opportunity to get to extend some parts of it. (11/n)

Excited to share our functional data that has helped classify VUS associated with immune dysregulation at #CIS2021 - what a great meeting! Check it out

Thanks for featuring Be Biopharma Longwood-founded #celltherapy #newco nature.com/articles/d4158…

Congrats to the hubs, Richard G. James, for cofounding Be Biopharma, over zoom, while simultaneously home schooling 6th grade! Exciting technology for the sustained delivery of protein therapeutics. Read more here ⬇️

Your work started King L Hung - we are super excited to keep it moving forward!

Check out our paper —>

Introducing NextTrevor, an open-source project to harness publicly available images of Trevor Bedford. We provide a continually-updated view of Trevor Bedford's evolution alongside powerful analytic tools. Our goal is to aid understanding and improve response to changes in his appearance.

B cells are nature’s medicine factories built to unleash a variety of therapeutic applications. Hear our scientific co-founders, Richard James (Richard G. James) & David Rawlings describe the incredible versatility of B cells. vimeo.com/646051754

Our paper is out in nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with Katie Yost, Howard Chang, Frank Xie lab, Zhe Liu, and others. (1/10) nature.com/articles/s4158…

Today we release in bioRxiv a method for isolating megabase-sized, oncogenic extrachromosomal DNA from human cancer cells. A collaboration with Howard Chang, Jens Luebeck, Siavash Raeisi Dehkordi, Vineet Bafna, Mischel Lab and others. (1/n) biorxiv.org/content/10.110…

Until the pre-print posts, I figured I would put together a thread for those who want to see the data. Many thanks to Wilfredo F. Garcia-Beltran, MD, PhD, @kstdenis29, Evan Lam, Adam Nitido, Vivek Naranbhai who have been up at all hours of the night both at the bench and writing the paper! 1/16

Join our team! DIRECTOR OF MUTATIONAL SCANNING This person will lead a team to help bring mutational scanning methods to production scale. Terrific job opportunity with Jay Shendure Lea Starita Details and how to apply here: bit.ly/3tpPdVo

Bianca Viray, a professor University of Washington, has been awarded the AMS Joan and Joseph Birman Fellowship for Women Scholars for the 2022–2023 academic year. An arithmetic geometer, Viray researches rational points on varieties. ➡ bit.ly/3sOzka9

Congratulations to Be Biopharma on the Series B! This Longwood-founded company is making progress in developing a new class of cellular medicines to help patients.

A really cool application of Partillion Biosciences and 10x Genomics technologies to measure secreted proteins together with single cell gene expression.

Very happy to see the full story out finally. We had been sitting on some of these exciting findings since 2017! (6/6)

New research published in Nature Communications from our co-founders Drs. Richard G. James and David Rawlings from Seattle Children's shows robust protein production and long-term engraftment of engineered plasma B cells. nature.com/articles/s4146… #BeBio #SCRI #Research #BCells

Prof. Nikolai Slavov Science Magazine Please take a look at this manuscript in collaboration with Richard G. James that also shows one should not make an assumption that transcript # is correlated to secretion of a protein. biorxiv.org/content/10.110…