This is awesome.

This is ridiculously cool. I wonder if the lack of spindle involvement is related to the speed of cell division, or differentiation-associated signs typically mediated by MTOCS. Pure speculation on my part.

Some days are good at work, some are excellent. Today was excellent.

Hundreds of paged that all turned out to be wrong

When you see images of seeming urban chaos in your feed, it is well to ask yourself: "Who created this image? Why? What happened just before? Just after? And what's going on just outside the frame the image-maker created?" (5/x)

whoa. cool.

Perhaps the most influential world model had its start as a predictive model. Before we had Newton's laws of gravity, we had Kepler's predictions of planetary orbits. Kepler's predictions led to Newton's laws. So what did Newton add?

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out!

omfg this is the coolest thing I've seen in a while

Can someone explain to me why cell culture media is so ridiculously rich in nutrients, and whether this causes significant deviations in metabolism or function relative to cells in vivo? I get why we do it--faster cell growth--but the trade-offs seem like they need to be assessed

always look out the airplane window.

normalize just doing things. i have little to no respect for authority—i have immense respect for those who routinely deliver.

The article itself is careful and deliberate about not claiming cGAS is the reason for the longevity of the naked mole rate. There is some evidence at the end it helps frail mice, though the reasoning appears at odds with genomic instability as the root cause, in my opinion.

Congrats to Broad Clinical Labs, Roche and Boston Children's Hospital for making a Guinness record for fastest genome sequencing! They were able to sequence and analyse the whole genome in <4 hrs, surpassing the previous benchmark of 5 hrs and 2 mins. A NEJM paper reports

The financial times are bad, but the decision to slash PhD cohorts is overdue. When NIH doubled and doubled, PhDs in the USA expanded wildly. Only very few, such as Caltech, kept their cohorts small, reasoning such richness could not last, and expansion was net unhealthy

C elegans cells would like a word.

I guessed 100-250k CRISPR users worldwide. I don't know the true answer, but it is certainly small. Compare that to >1 million Java developers certified by Oracle alone. Biology, the thing we all are, the thing that makes us live or die, is something barely anybody works on

"MultiCAST, a streamlined platform for rapid and scalable gRNA-directed transposon insertion in bacteria."

Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. science.org/doi/10.1126/sc… (1/9)

Currently at #TERMIS2025, sitting at an award plenary, and though the speaker has done amazing science and is a great speaker, 100% of the data she presented is 2008-2018. Why? I can read all of these papers. The point of conferences used to be to show cutting edge work.