I am excited to share our work, out now in The Lancet Neurology, showing cell-based measures of gamma-secretase activity and amyloid production predict clinical, cognitive and biomarker features in autosomal dominant AD. Link to paper: tinyurl.com/ye2a3d5u Alzheimer's Association #AAIC

An amazing story ❤️

Happy to have been able to make a tiny contribution to this beautiful work by ⁦Zhao Sun⁩ and Andrew Yoo… Modeling late-onset AD neuropathology via direct neuronal reprogramming ⁦@WUADRC⁩ science.org/doi/10.1126/sc…

How presenilin mutations shift γ-secretase’s output of short versus long Aβ peptides explains the speed of pathogenesis and age at onset, supporting GSM development. MGH Neurology Stephanie Schultz Alzheimer's Association #AAIC ow.ly/kywN50SZrFm

This week, Dr. Reisa Sperling returns to the podcast to explore the different factors that can impact cognitive decline and early-stage #Alzheimers disease. Listen to her conversation with Nathaniel Chin on our website at go.wisc.edu/13yj88 or wherever you get your

Caesar delayed the Rubicon, King Arthur’s still wrangling stats with Merlin 🧙‍♂️, Michelangelo cracked his marble 🛠️, and Napoleon? He’s fine-tuning his graphs! 📊 SO… we’re pushing the abstract deadline to Tuesday, October 29, at NOON (US ET) ⏳ #HAI2024 #AbstractMadness

🙌 Design and Data Analytics PIA & Reserve, Resilience and Protective Factors PIA offer you a unique "#Resilience in #CognitiveAging" Webinar Series! Join us if you can 😎 Registration DEC 6 👉 tinyurl.com/3z8x9f4e DEC 11 👉 tinyurl.com/y7wmdw6y Yakeel T. Quiroz, PhD (she/her) Emily Rogalski Rory Boyle Eider Arenaza-Urquijo Ana Capuano David Bartrés-Faz

Having started my career in basic neuroscience research, I have always understood Alzheimer disease to mean the pathophysiology associated with amyloid plaques and tau tangles. As a clinician, I appreciate that the relationship between Alzheimer disease and cognitive impairment

Trajectories of neurofilament light chain (a presumed marker of neurodegeneration) in CSF and blood over the entire course of (autosomal dominant) #Alzheimer's disease. doi.org/10.1038/s41467… Great collaboration with Stephanie Schultz @DZNE_en Hertie-Zentrum für Neurologie

Our latest study out today! Findings reveal PSEN2 variants with known PSEN1 homolog variant show abnormal Aβ production patterns strongly correlated with age at symptom onset, while non-homologous PSEN2 variants often exhibit wild-type-like Aβ ratios doi.org/10.1002/alz.14…

Beautiful work by Liu et al. highlighting the importance of heterogeneity in amyloid-beta pathology, especially in the era of amyloid targeting therapies. I remember seeing this work at ADPD and am excited to see it published! Dr. Elizabeth Head Michael Miller jamanetwork.com/journals/jaman…

🔔👉CognitionPIA members, we need your input! In preparation for our ISTAART Cognition PIA 2024 Year in Review webinar, please fill out this survey to submit publications & advancements from 2024 that you would like us to highlight. Deadline *Dec 9th*! 🙏alz.surveymonkey.com/r/SLH6BMW

Excited to share our Framingham Heart Study paper in ANA Journals!🧠 Sex-specific links between stroke risk factors and subclinical vascular brain injury support tailored prevention strategies in aging.👇doi.org/10.1002/ana.27… Big thanks to Sudha Seshadri, MD, Alexa, Matt, Rachel Buckley 🐨🇦🇺🐨 & team!

In familial symptomatic Alzheimer's, NfL in CSF may track neurodegeneration more closely than in blood. MassGeneral News ow.ly/YKVp50UmNig

Wonderful summary of our results, thank you Alzforum. NfL is becoming so important as a readout in clinical Alzheimer trials! Do CSF and Plasma NfL Diverge After Alzheimer’s Disease Onset? alzforum.org/news/research-…

In preparation for the Reserve, Resilience and Protective Factors PIA year in review webinar in January, we are compiling the most important papers published last year about 🧠 reserve and resilience. Please, consider helping us finding the papers by completing the survey alz.surveymonkey.com/r/SLH6BMW

🎉Congratulations Betty Tijms! She has been awarded a European Research Council (ERC) Consolidator Grant. With nearly 3 million euros in funding, she will investigate whether the 5 biological variants of Alzheimer’s disease respond differently to medication: amsterdamumc.org/en/research/in… Alzheimercentrum Amsterdam (inactief)

Excited to share our recent paper! We use genetics, bioinformatics, and cell-based studies to determine whether variants of unknown significance act as pathogenic variants to cause autosomal dominant Alzheimer’s disease Alzheimer's Association WashU Medicine Knight ADRC sciencedirect.com/science/articl…