Because videos are more fun

Such a cool application of HS-AFM in indirectly probing T-sensitivity of TRPs. But the fluctuations NEED to be enthalpically distinct to contribute to DeltaCp and if not then it would mean something else. pnas.org/doi/10.1073/pn…

Introducing OPUS-DSD, an algorithm that efficiently reconstructs the dynamic structural variation landscape embedded in macromolecular cryo-EM data. OA paper: nature.com/articles/s4159…

As everyone celebrates and congratulates new Nobel Prize winners, I turn attention to another group of scholars, celebrating their work eg. “Why many scientists like to lick rocks…” 🧐 improbable.com/ig/winners/?am…

nature.com/articles/s4158… My first paper as a postdoc in the lab David Drew is out Check-out the.first structure of a unique transporter which is regulated by a voltage sensing domain. Great team work!!

It’s bitter-sweet to see this paper out, along with its twin, but a validation that we’re picking important and challenging questions and pursuing them aggressively and in many ways, not too far behind!

It’ll be great to have a new postdoc in my group to lead a new project (biochem/biophys/ephys). If there’s anyone out there who wants to chat, message me. I might be a little weird, but the proteins we’re interested in are weirder!

A-M-A-Z-I-N-G: a facultative channel, a facultative transporter…

I will print this in big letters! Jan Lowe’s thoughts on Kiyoshi scientific life…

Know an undergrad student, fascinated by the brain, who hasn't had an opportunity at their institution to pursue neuroscience research? Pls share about our iDREAM 2yr postbacc program in neuro! Jan.11th virtual info session.

Our new pre-print: polyamorous BK channel now engaged to the Gamma subunit! How the TM and LRRD of Gamma influence its union with BK… Also the transporter model of VSD activation: a rotameric flip is all it takes to riot! A flipping journey!! biorxiv.org/content/10.110…

The ultimate result of championing only hypothesis-driven science is to fill the world with scientists who care more about their hypotheses than exploring for an unexpected discovery.

Challenging my TRPVs and TRPAs.. Spice level 5! It burns, burns, burns… the pot of fire!!!

We are thrilled to announce that the recipient of the 2024 Kenneth S. Cole Award is Dr. Benoît Roux from the University of Chicago. Join us in congratulating Dr. Roux! 🎉 #KennethSColeAward biochem.uchicago.edu/faculty/benoit…

The best opening line in any physics textbook: States of Matter by David L. Goodstein ✍️

Our lab at the Univ of Maryland has an NIH-funded #postdoc vacancy to investigate the structural basis of #SARSCoV2 hijacking of host trafficking #proteins. We use #cryoem, #Crystallography, & #OctetBLI. And #Rockville is an aewsome place. IBBR University of Maryland, Baltimore UMD Department of Chemistry & Biochemistry

Now this could be a game changer (APPEARS TO BE sooooo much easier than affinity grids!)

It’s BACK!!! air, water, earth and fire!!! Yip, yip!!

It’s sometimes funny, sometimes odd that some people find it necessary to mock others to prove their point. There’s value in “collective wisdom” and time being the “controversy settler”. GABA receptors are supposed to calm it down not elicit nastiness