Absolutely thrilled to see this work finally published! About 15 months ago I started on a journey which I could not have imagined before… Interested in the story behind the scenes? My first-ever thread. 1/n

What a week, second publication within seven days 😍. This time it is about human geneticist again. Thanks to the talented Julia who led this work, amazing collaboration partners Elizabeth Leslie Justin Cotney Nina Ishorst Alvaro Rada-Iglesias and many others 🥳

Our team work of 30 humans, one alpaca and one llama on #Nanobodies to fight #SARSCoV2 has been recognized by Falling Walls as one of the winners in Life Sciences #ScienceReunitesUs Rheinische Friedrich-Wilhelms-Universität Bonn Uniklinik Bonn CFNanobodies_Bonn Martin Hällberg Nicholas Wu

CRISPR technologies are powerful gene editing tools because they are programmable. We are excited to describe 3 new programmable systems, IscB, IsrB, and TnpB, some of the most abundant genes on the planet, with potential for gene editing. Science Magazine science.org/doi/10.1126/sc…

Please check out the twitter thread about our recent paper! Huge thanks again to everyone involved in this effort!!!

Excited to see our work in the ZLab Feng Zhang on the protease Csx29 out! Led by the amazing Jonathan Strecker with beautiful structures driven by Esra Dimircioglu, we show that Csx29 complexed with CRISPR protein Cas7-11 (aka gRAMP) is an RNA-triggered protease. science.org/doi/10.1126/sc…

Our story on NLRP3 priming is now out in Immunity after 5 years in the making. We found that IKKβ primes the inflammasome by recruiting NLRP3 to the trans-Golgi network. This allows the NLRP3 inflammasome to form independently of NEK7. Summary👇 authors.elsevier.com/c/1g5G03qNrUqG…

Read the story about a #CRISPR related, second messenger activated #protease that triggers a complex prokaryotic immune response @nature: nature.com/articles/s4158… (2/3)

Very happy to share our study on the type III CRISPR CalpLTS cascade, which has been published today in nature. nature.com/articles/s4158…

Thank you ImmunoSensation for two days of inspiring discoveries and interactions, and most proud congratulations to our @K__Blumenstock for winning this year's Best Talk Award! Rheinische Friedrich-Wilhelms-Universität Bonn Uniklinik Bonn

Congratulations to the #HighlyCited2023 researchers! Especially to our Cluster members Joachim L. Schultze, Eicke Latz, Jonathan Schmid-Burgk, SchlitzerLab and Thomas Bieber.

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/