Last week, I shared GEDI, our model for interpretable integration of cohort-level single-cell data (biorxiv.org/content/10.110…). One of GEDI's abilities is cluster-free differential expression analysis. What does it mean, and how do we do it? 1/15

Transfer RNAs (tRNAs) are increasingly found to play dynamic and critical regulatory roles in cancer progression. Alexandra Pinzaru's review describes this exciting area of research: nature.com/articles/s4156…

Thank you all for the organization! An amazing meeting! Interesting science, discussion and sharing! A lot of fun there!

Today’s happiness stemmed from the arrival of Uri Alon’s new book

Thank you for having us Arc Institute!

This is super cool! Full Central Dogma from imaging!

Thrilled to share our latest review on translational adaptation in breast cancer metastasis and the promising therapeutic opportunities it unveils! Immense thanks to Hani Goodarzi and Albertas Navickas !

The April 2024 issue of Cell Press Trends in Pharmacological Sciences is online now. cell.com/trends/pharmac… On the cover: Translational adaptation in breast cancer metastasis Albertas Navickas @Institut_Curie Siyu Chen Hani Goodarzi UCSF Biochemistry UC San Francisco

tRNAs for the win!

2 articles on gene drives: - "Overriding Mendelian inheritance in Arabidopsis with a CRISPR toxin–antidote gene drive that impairs pollen germination" rdcu.be/dK2mz - "Cleave and Rescue gamete killers create conditions for gene drive in plants" rdcu.be/dK2nD

Postdoctoral Fellow in Computational Biology Hamed Najafabadi We are looking for a postdoctoral researcher to join our efforts in understanding the gene regulatory basis of cell identity and human diseases. jobrxiv.org/job/mcgill-uni… #bioinformatics #compu... jobrxiv.org/job/mcgill-uni…

First month as #newPI is in the books. Check out my lab website to learn more about the lab and opportunities. We have openings at all levels. If you are interested in cryoEM/cryoET to work on stress signaling pathways, please reach out. sites.northwestern.edu/sangwan/

One of the last two papers from my work in AkbarianLab is out! Another extremely collaborative effort to profile tRNAs in conjunction with the proteome and amino acid content in brains of MDD patients who died by suicide. nature.com/articles/s4138…

Check out our latest preprint, led by Siyu Chen, that brings together an amazing team of scientists from several labs to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? biorxiv.org/content/10.110…

Evolution is more like a tinkerer than an engineer. New things happen not by perfect engineering but by working with what's already available and repurposing existing objects through recombinations and modifications. This lesson holds for any innovation, including new ideas..

If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA! events.faseb.org/event/RNA-Proc…

In the latest issue! Advancing protein evolution with inverse folding models integrating structural and evolutionary constraints dlvr.it/TMgfcC

Our paper ‘Genetics–nutrition interactions control diurnal enhancer–promoter dynamics and liver lipid metabolism’ is now online Cell Metabolism. You can download it for free before Oct 14 via this link: authors.elsevier.com/a/1lfk85WXUlaY…