Interested in #organelle biogenesis, subcellular #protein targeting, physicochemical #membrane properties or #LipidMetabolism? 👉We are hiring #PhDstudent #postdoc Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry

Congrats to MCB's James Olzmann James Olzmann on being named a 2025 ASCB Fellow! American Society for Cell Biology 👏🎉

With Christoph Gorgulla, StJude and Haribabu Arthanari, Harvard. AdaptiveFlow screens ultra large libraries of 70 billion compounds. We discover #coenzymeQ inhibitors of #ferroptosis suppressor protein #FSP1 validated experimentally and crystal structures biorxiv.org/content/10.110…

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB UC Berkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098

👉New publication from our lab: tinyurl.com/ye7pntte The protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes

What if treating disease meant stabilizing biology, not blocking it? We explore that idea in Science Magazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. science.org/doi/10.1126/sc… #mycompnay

Check out how we repurpose lysosomal membrane proteins for targeted protein relocalization and degradation using LYMTAC molecules. Now published in Nature Communications. Congrats to Dhanusha Nalawansha and team! #mycompany nature.com/articles/s4146…

First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science. A few benches are still waiting for curious minds: Come, join us! #AcademicJob

New preprint from Raffaella De Pace in our lab @NICHD_NIH in collaboration with Adeline Vanderver at Children's Hospital and colleagues reporting mutations in the endolysosomal motility and fusion regulator BLOC1S1 in children with a neurodevelopmental disorder medrxiv.org/content/10.110…

Happy to share an exciting study from Yihong Ye’s lab NIH, with a minor contribution from our lab: CLN4-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉rdcu.be/eChof

I'm thrilled to share our work from Jonathan Weissman's Lab (sciencedirect.com/science/articl…). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

Thank you all for this tremendous work on a therapeutic target that is extremely challenging to degrade with a PROTAC. "Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse" 👏👏👏nature.com/articles/s4138…

The #MaxPlanckPostdocProgram offers a guaranteed contract of at least 3 years, targeted mentoring, and career workshops. The call for applications is open now! 🚀 Take advantage of this opportunity and browse the job vacancies. mpg.de/en/max-planck-…

Another long standing question maybe revealed, why does 60s subunit detaches slowly once translation terminates? UFMylation controls 60s ribosome recycling and deUFMylation would release the subunit, by Francesco Scavone – Stanford University. #EmblProtein EMBL Events

Humbled and honored to receive the 2026 Avanti Award in Lipids from ASBMB! Grateful to my exceptional lab, mentors, and collaborators for their support and inspiration. Excited to keep pushing the boundaries of lipid biology and therapeutics! asbmb.org/asbmb-today/pe…

Happy to share the latest work from the Deretic Lab. We demonstrated that ATG16L1 regulates V-ATPase. Hope you all enjoy the data.

From MBoC... Francesco Scavone (Stanford) shows ATG9A has an unexpected role in trafficking K63-polyubiquitin–modified membrane proteins. Blocking the signal traps cargos in vesicle clusters; once released, they rapidly reach lysosomes. 🔗 molbiolcell.org/doi/10.1091/mb… #ASCB #CellBiology

Today’s NCB. The cytoplasmic intrinsically disordered regions (IDRs) of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for the ER and mitochondria fragmentation required for lysosomal clearance of the organelle’s portions. rdcu.be/eF5DR

Sergej Djuranovic is looking for a new postdoctoral fellow interested in the further development of our RAPPL technology and studies of translational complexes in bacterial or eukaryotic cells. Preference will be given to candidates with either structural biology or ribosome

Big news! Our group has joined the University of Hamburg — we’re excited for the opportunities and collaborations ahead! #Hamburg