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Out just in time for my last days Caltech pnas.org/doi/10.1073/pn…

The David Savage lab (HHMI, UC Berkeley & the Innovative Genomics Institute are laying the groundwork for enzyme engineering efforts. Read their latest work below! Thank you to the authors for choosing Twist Bioscience DNA to support this work. 🧬 nature.com/articles/s4158…

Savage Lab Michael Prywes Congratulations Savage Lab on the publication of this beautiful story!

Excited to share our new preprint on mutational scanning of the TnpB RNP! We identify several highly activating, single-position mutations in TnpB’s protein and reRNA. These datasets enabled us to engineer enhanced TnpB protein variants (>50x plant editing levels compared to WT).

This January we launched the 3rd cohort of the African Plant Breeding Academy CRISPR Course! I spoke with the Innovative Genomics Institute about this one-of-a-kind training, and how CRISPR is unlocking new possibilities for African crops. Link: innovativegenomics.org/news/californi…

Check out our pre-print on ProteinGuide, a new method for conditioning protein generative models on experimental data! Thanks to the amazing team: Junhao (Bear) Xiong, Hunter, Jennifer Listgarten, Ishan Gaur and Luke Oltrogge! Savage Lab