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A great paper in nature asking how reducing calories everyday or fasting for 1-2 days a week can increase lifespan in genetically diverse female mice. - Genes have more influence on lifespan than dietary restriction. - metabolic health does not necessarily predict lifespan -

Snoring is the alarming sound of a faster running aging-clock. cell.com/trends/molecul… Trends in Molecular Medicine

Lack of daylight and bright light at night is associated with a higher risk for metabolic- and heart disease PNASNews Sean W Cain Joseph Takahashi pnas.org/doi/10.1073/pn…

In this episode Jamie Justice Jamie Justice, Exec Director of XPRIZE Healthspan of discusses biomarkers of aging, XPrize healthspan challenge and explains why healthy longevity is for everyone. XPRIZE youtube.com/watch?v=W5chwT…

Prof Phyllis Zee, director of the Center for Circadian and Sleep Medicine (CCSM), and past president of the Sleep Research Society, discusses - Different types of sleep problems - What can you do to improve sleep - When to see a sleep doctor youtube.com/watch?v=DmbrgJ…

Most of the TRE studies are on -people with overweight and obesity with no other metabolic disease and - the primary outcomes are often weightloss. These studies show TRE works for weightloss. But The Wall Street Journal @alexLjanin misses this point about how clinical trials are done and

Happy Holidays and Happy New Year!! Wish you a healthy, happy and prosperous 2025!

Excited to be among some of the great thinkers and writers of our time.

This morning with General Petraeus at Rancho Mirage Writers Festival in Palm Springs. It was fun sharing a few tricks for managing jet lag and discussing Circadian Code with General Petraeus.

Why some animals have unusually long lifespan and what we can we learn from nature to potentially increase human healthspan? Steven Austad, Scientific Director of the American Federation for Aging Research and author of the book "Methuselah's zoo" shares his wisdom in this

This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. Erquan Zhang Susan Golden @ Society for Research on Biological Rhythms rdcu.be/efxV8

Which allele is expressed in which tissue is the key to assessing if a disease-causing allele will compromise health. Yet, we dont know this even in young animals. This paper from our lab reveals 60+% of protein coding genes are allelically imbalanced in any tissue. Seminal work

Metabolism and Physiology in animals and humans show strong daily rhythms, yet in most preclinical animal experiments, researchers dont consider the time of day when physiological or metabolic measurements are made. Shaunak Deota from my team Salk Institute took the lead in

People often talk about "Chronotype" - whether they are early bird or night owl. Prof. Till Roenneberg and colleagues have led decades of studies on chronotypes, sleep, and social jetlag. In this podcast he discusses these topics that are relevant to everyone's health and

Warm feet at bed time can make you fall asleep faster. This classic paper from 1999 used multiple temperature sensors, and sleep recording on study volunteers and found warm feet and cooler body made people fall asleep in ~10min after lights out. nature.com/articles/43366

Great to see women who were trained to do HIIT and TRE were more likely to follow this protocol over 2 years. TRE+HIIT sustained muscle mass, and reduced abdominal fat. nature.com/articles/s4159…

Excited to be a semifinalist for #xprizehealthspan !!! #TeamCircadian of Salk Institute will use the biological principles of circadian rhythm to extend healthy lifespan. Emily Manoogian salk.edu/news-release/s…

Chronic diseases are robbing at least a decade of life from the US adults (compared to peer developed nations). wsj.com/health/wellnes… Improving #circadianryhythm by #TRE or #intermittentfasting, better sleep can give back years of healthy life.

Laura van Rosmalen is presenting her seminal work on a preclinical model of relative energy deficiency in sport at the Female Athlete Conference , Boston. ⁦Wu Tsai Human Performance Alliance⁩ ⁦Salk Institute⁩