Dear cryo-EM women scientists, We want to honor you and your contributions at BPS 2025. This year, the Cryo-EM subgroup will honor a mid/senior-career woman scientist as the inaugural June Almeida awardee. June Almeida is the virologist who first discovered the coronavirus in

Im so proud and excited to report that our very own talented graduate student Maymay Mu is one of the recipients of this years 2024 Audree Fowler Fellowship in Protein Science Very well deserved honor! UCLA Biological Chemistry UCLA MBI

CS vs RelionCor/CtfFind4 on the same 100 movies. Tried pretty much every setting in RelionCor/CtfFind4 but cannot get the CTF to be estimated well. The movies look good by eye and Thon rings are visible. Any ideas what to try if I was commited to use Relion/CTFfind?

This is damning. Another cryo-EM retraction and a paper based on zero data onlinelibrary.wiley.com/doi/10.1002/ad…

"Ever wondered how α-latrotoxin, the black widow spider's 🕷️ neurotoxin, turns into a cation-selective channel? Check out our latest manuscript! rdcu.be/dWez3 Nature Communications #Neuroscience #Toxin #cryoEM @Sfb1348 Universität Münster

Maymay at her award seminar this morning. Many congratulations!! Very well deserved!

I would like snack on a bottle of #sigmaaldrichchocolate to fuel my science. Thanks Merck Life Science

New preprint out from the MonteRosa gang on computational approaches to mine the CRBN target space. Revealed new neosubstrates recognition modes including helical motifs and molecular surface mimicry. Lots to still learn about redirecting CRBN! biorxiv.org/content/10.110…

Yesterday a Nobel prize was given for alpha fold. Alpha fold could not exist without the Protein Data Bank (PDB), a public database funded by US taxpayers. Every structural biologist in the world that deposited their structure to the PDB indirectly helped train alpha fold.

Filomeno Sánchez Rodríguez et al.: Using deep-learning predictions reveals a large number of register errors in PDB depositions #DeepLearning #ProteinDataBank #StructureValidation University of Liverpool University of York... #IUCr journals.iucr.org/paper?S2052252…

It's happening! We're excited to be hosting ~300 attendees for the 9th SoCal CryoEM Symposium USC tomorrow. USC Dornsife College of Letters, Arts & Sciences USC Bridge Institute dornsife.usc.edu/bridge-institu…

👀❄️🔬Check it out from Jae Yang, Josh Mitchell, Craig Bingman, Deane Mosher, & me!! Tour de force of #cryoEM, #microED, #cryoET, & #cryoFIB to solve the in situ crystalline structure of the #Eosinophil major basic protein-1! biorxiv.org/cgi/content/sh… Congrats! ⁦UW–Madison Biochem⁩

hey #teamtomo if you are looking to add to your toolkit for molecular identification inside cells, our preprint is now out!

Hi all #cryoem folks, just a reminder that nominations for the inaugural Almeida award of the BPS CryoEM Subgroup close November 1st, so please get your nominations submitted ASAP! Please submit to [email protected], details in post from Liz Kellogg ❄️🔬 below!

Glad to see this online in PNASNews (pubmed.ncbi.nlm.nih.gov/39352935/). I started this project many moons ago at Caltech. While trying to dissect the Legionella Type 4 Secretion System (T4SS), I found deletion of two T4SS components (dotI/dotJ) abrogates ATPase recruitment.

Vogel lab (WashU) had similar conclusions from their biochemical analysis. We decided to dig deep! Sukhi spent nearly 3 years doing meticulous biochemical and genetic analysis to show that DotJ, DotI, and IcmT are receptors for the T4SS’ unique 3-component ATPase complex.

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2