Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo biorxiv.org/cgi/content/sh… #biorxiv_cancer

Excited to see the result of this amazing collaboration Anand Patel MD PhD Claudia Yun Wei Langenau Lab finally out

ST-EPNs segregate into molecularly and clinically distinct subgroups, hinting at different developmental roots. But what are the developmental signatures and microenvironmental factors driving these tumors’ behaviors? 2/

To answer these questions, we integrated single-cell & spatial transcriptomics with live cell imaging to map cell states, spatial organization, and dynamic behavior. 3/

We found that tumor subgroups harbor two distinct progenitor-like cell states reminiscent of early human brain development and diverge in the extent of neuronal vs ependymal differentiation. 4/

Next, we used 10X Xenium to characterize where these cells are, and by combining with H&E we could derive transcriptionally and morphologically distinct regions such as these distinct ependymal rosettes: 5/

Similar to findings from Tirosh Lab in gliomas, we see distinct structured vs non-structured regions that are driven by MES/hypoxia, with recurrent patients having more structure and more MES! 6/

Finally, we identified cell states with distinct morphology and behavior only in the presence of brain-resident cells. 7/

Huge thank you to our collaborators Varun Venkataramani, @Pajtlerlab and all co-authors for helping this come together! #BrainCancer #spatialbiology

Check out this exciting project deciphering cellular and spatial heterogeneity and neuronal influence on different cell states in supratentorial ependymoma! Biggest congrats to everyone involved!

I'm delighted to have this paper available after so much hard work! Congrats, Daeun Jeong and Sara Danielli!!!

Couldn’t be happier to see our work on resolving cellular and spatial heterogeneity, and the influence of the microenvironment on driving cell states in pediatric ependymomas out as a preprint 🔥 biggest congrats to Daeun Jeong, Mariella Filbin and all the collaborators 🥳

Our recently published manuscript in Cancer Cell – Diffuse hemispheric glioma, H3G34R/V-mutant (H3G34-DHG) - cell.com/cancer-cell/fu…

So excited to announce that I am going to start my research lab at UT southwestern on January 2025, to study cancer cell state dynamics and epigenetics! Currently recruiting postdocs, research technicians among others! Check out my lab website with the QR code for more info!

When you share the floor with the most fun labs..Happy Halloween from the Filbin lab, Stegmaier Lab and hovestadt lab @dfci! 🎃👻💀

Also having the most amazing lab members 🫠🫠🫠

So grateful for being awarded with the Young Investigator Award from CTOS!⚡️Such a great time in San Diego presenting a collaborative study with Langenau Lab , Claudia Yun Wei and Anand Patel MD PhD, making new friends, and celebrating at the USSMidwayMuseum 🎇🥂#CTOS2024

Thrilled to share our work Mariella Filbin, @GojoJohannes, and Carl Koschmann, now published in Cancer Cell. We present a translational approach identifying the PDGFRA inhibitor avapritinib as a novel targeted treatment for pHGG with PDGFRA alterations. cell.com/cancer-cell/fu…

Nature research paper: Comprehensive interrogation of synthetic lethality in the DNA damage response go.nature.com/42DHxzK