Another group has more or less reproduced AF3, but has built in a way to add spatial constraints for PPI prediction. These constraints lead to huge increases in fraction of models that are correct-ish, without changing fraction that is high-accuracy chaiassets.com/chai-1/paper/t…

A tour de force from Carl Wu's lab Johns Hopkins University .- lead author postdoc Robert Louder: Molecular basis of global promoter sensing and nucleosome capture by t... sciencedirect.com/science/articl…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Pleased to present our first preprint on how de novo DNA methylation occurs in di-nucleosomes. Lots of surprising findings about the linker length dependence of DNMT3 binding and activity. A great collaboration with the Peter Jones lab Van Andel Institute (VAI). tinyurl.com/47pmv7hy

Trick bacteria with light! It took us a very long time to publish this work, but perseverance and teamwork prevailed. @ Ryan McQuillen Xinxing Yang @ Amilcar Perez @Malcolm Winkler @ Erin Goley @ Kumaran Ramamurthi nature.com/articles/s4146…

Excited to relocate my lab to Johns Hopkins University and join as a Bloomberg Distinguished Professors! We are actively recruiting at all levels—seeking talented scientists passionate about cracking the codes of the epigenome. Let’s push the frontiers of transcription, DNA repair, and structural biology together!

Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.

Thrilled to share that my work from postdoctoral research has been published in nature . Huge thanks to my mentor Dr. Edward Twomey, and collaborators Elisa Carrillo and Prof. Vasanthi Jayaraman. nature.com/articles/s4158…

At this point, I don’t think anyone’s job is safe at HHS. What an insane move…

📢 Call for proposals: Boltz small-molecule design collaboration! 🧬 Can we help design your ideal molecule? Can you help us improve our open-source models? Please reach out or share with scientists you know! More details below! It has been great to see the level of excitement

Very pleased to share a recent Stephen Fried JHU publication, in which we show how an #IDR modulates the substrate specificity of a yeast histone deubiquitinase, Ubp10. 1/5 #FriedLabNews onlinelibrary.wiley.com/doi/10.1002/pr…

Please see our review article in NSMB, “Mechanisms and genomic implications of BIR”. Adel Atari and Haoyang Jiang focus on mammalian BIR, its relationships to human disease, and genome engineering. Thanks to reviewers for helpful comments. nature.com/articles/s4159…