Breaking down causes, consequences, and mediating effects of #telomere length variation on human health Genome Biology 🧬🧬 Thanks to @ Samuel Moix Zoltán Kutalik Chiara Auwerx et al. genomebiology.biomedcentral.com/articles/10.11…

Genome analysis adds to mounting evidence against the idea that Rapa Nui’s population collapsed owing to overexploitation of natural resources go.nature.com/3AYW5yR

Call for PhD in quantitative Biology!! Applications open ... unil.ch/quantitative-b… #PhD #computationbiology #quantititivebiology

Just landed in Denver for #ASHG24 with the Zoltán Kutalik team (Adriaan Samuel Moix ) ! If you’re attending, don’t miss our group’s new research at poster boards 4137F and 4095T, and during a platform talk in the pharmacogenomics session on Friday at 11am.

Thrilled to be presenting at the Pharmacogenomics session at #ASHG24 today at 11am! Stop by if you're curious about exploring causal relationships between drugs, diseases, and proteins. See you there!

Hello #ASHG24! Curious about how we can determine the parental origin of both transmitted and untransmitted alleles? Come check out my poster 4137 this afternoon!

Excited to share our recent work: expansions and contractions of DNA repeats have produced many genetic polymorphisms. We studied repeat instability among >700,000 biobank participants using new computational approaches to analyze DNA sequencing data. biorxiv.org/content/10.110…

🚨 Our preprint on parent-of-origin effects (POEs) is out! With our new method, we inferred the parental origin of >220,000 individuals, revealing new insights into the genetic architecture of complex traits. 👉 Read here: medrxiv.org/content/10.110… 👇 Highlights below!

Just out in Nature Human Behaviour 👇🏼👇🏼 We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of genome-wide findings

FastOMA is out now in Nature Methods 🎉: nature.com/articles/s4159… A new orthology inference algorithm that scales linearly and is highly accurate. FastOMA can process all >2000 eukaryotic UniProt ref proteomes <24 hours 🚀. Try it out at github.com/DessimozLab/fa…

🚨 Preprint update! We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals! Discover fresh insights into the genetic architecture of early growth! Updated preprint: medrxiv.org/content/10.110…

Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants! Nature Communications Here, we used simulation work + longitudinal GWAS to explore risks involved in cognitive/physical decline (1/)🧵🧵 shorturl.at/99gqL

🎉 Hi #ESHG2025, the Statistical Genetics Group and alumni (Zoltán Kutalik ) is coming in force! Check out our latest work on human genetics! 📍Come see our talks & posters, or reach out to meet us! Chiara Auwerx Mihaela-Diana Zanoaga Samuel Moix Adriaan Théo Cavinato Dept of Computational Biology, Uni Lausanne

Extremely proud of Robin Hofmeister for his European Society of Human Genetics (ESHG) Early Career Award received yesterday in Milan. A richly deserved recognition of his outstanding presentation and ingenious research on parent-of-origin effect inference! #ESHG2025

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! nature.com/articles/s4146…

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵

🚨 Our parent-of-origin study is out in nature ! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗nature.com/articles/s4158… Highlights below!

🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. 🔗biorxiv.org/content/10.110…

Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! Clara D. Pailler, Leona Knüsel, Mihaela-Diana Zanoaga, Robin Hofmeister, Adriaan, Théo Cavinato, Dept of Computational Biology, Uni Lausanne