Elated to see the neuropathology community, strong and growing, at the forefront of discovery in neurodegenerative diseases #tau2020 Alzheimer's Association The Rainwater Charitable Foundation. Salvo Spina #Alzheimers

Progressive supranuclear palsy and primary lateral sclerosis secondary to globular glial tauopathy: a case report and a practical theoretical framework for the clinical prediction of this rare pathological entity tandfonline.com/doi/full/10.10…

Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological & neuroimaging correlates. Pts w/FTD-MND can present w/language symptoms (nfvPPA & svPPA) vs exclusively bvFTD. bit.ly/3cJ8VzH ALBA Language Neurobiology laboratory Salvo Spina Lea T. Grinberg, M.D, Ph.D Zachary Miller

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg( SNCA *A53T) mouse lines. Confirmed transmission of α-synuclein prions to a second synucleinopathy model. bit.ly/2VRedTZ Salvo Spina Lea T. Grinberg, M.D, Ph.D

Letterio Politi and Ettore Salsano, my great friends’ important manuscript on COVID-19 and the brain.

You know, I had figured that normal life could resume sometime this fall. But the magnitude of the US failure — and the retreat into denial, which will just extend the crisis — just boggles the mind

Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging and Autopsy in a Case of PSP. Case with antemortem CSF Aβ1-42 (+)/amyloid PET (-) may indicate CSF Aβ1-42 is more sensitive for assessing in vivo Aβ than amyloid PET. bit.ly/2ZKPiDI Salvo Spina

Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations. ARTAG pathology is frequent and correlates with older age and higher Braak stage. bit.ly/3jyOsC3 Elisa Resende @cathrinepet Salvo Spina Zachary Miller Lea T. Grinberg, M.D, Ph.D

Beautiful paper also demonstrating very similar findings of the ones that we reported in human with primary tauopathies, PSP and CBD. bit.ly/2EAF3XD

Brain volumetric deficits in MAPT mutation carriers: a multisite study. A subset of presymptomatic carriers showed low volumes in mesial temporal lobe, the region atrophied in all symptomatic carriers. bit.ly/34f9rnf ALLFTD Suzee Lee Salvo Spina Jennifer Yokoyama

Impressive work by our colleagues Martin Kampmann Lea T. Grinberg, M.D, Ph.D Salvo Spina Claudia Suemoto MD PhD MSc Roberta Diehl Rodriguez et al identifying AD vulnerable cells using snRNA-seq and histology UCSF MAC

Our paper with Georges Naasan Lea T. Grinberg, M.D, Ph.D Salvo Spina and the Seeley Lab came out in Brain today!

New insights on the genetics and neuropathology of PSP and CBD in this work led by James Rini. tandfonline.com/eprint/EW5Q8SJ…

18F-flortaucipir PET to autopsy comparisons in Alzheimer’s disease and other neurodegenerative diseases. bit.ly/39yV3c5 @leoiacca @relajoie Lauren Edwards Berkeley Neuroscience LBNL BioSci Salvo Spina Amelia Strom Julie Pham Lea T. Grinberg, M.D, Ph.D Taylor Mellinger Rana Eser and more!

Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease. Non-AD pathology plays an important role in the clinical phenotype of EOAD. bit.ly/3wsP56B Salvo Spina @relajoie @cathrinepet Lea T. Grinberg, M.D, Ph.D @RabLab_UCSF Bruce Miller Oxford Academic

Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology. Review of neuroimaging and the phenotypic & pathologic features of FTD spectrum, as seen on MRI & PET. bit.ly/2YI0hjg Brad Peet Salvo Spina Nidhi Mundada @relajoie

Copathologies contribution to tau aggregation and spread in Alzheimer’s disease! Looking forward to hear about your work!

"Increased diversity of autopsy cohorts is key to...our understanding of neurodegenerative conditions." Congrats Charles Windon 2022 GBHI Equity Award winner for project w/ Salvo Spina which will foster more inclusive research 👏UCSF School of Medicine UCSF MAC gbhi.org/news-publicati…