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mRNA transport on lysosome-related vesicles is critical for the maintenance of axonal homeostasis and its failure causes axonal degeneration in human iPSC-derived and mouse neurons Raffaella De Pace Saikat Ghosh Juan S. Bonifacino NICHD News nature.com/articles/s4159…

Axons or Bust: To Reach Neuron Extremities, RNAs Hitch a Ride on Lysosomes alzforum.org/news/research-… Thank you Alzforum for highlighting our recent study. #NIH #NICHD

Excited to join the iPSC engineering workshop The Jackson Laboratory #iNDI jax.org/education-and-…

Thank you, Ingrid Fadelli and medicalexpress.com for covering our work! Study finds that the transport of mRNAs into axons along with lysosomal vesicles prevents axon degeneration medicalxpress.com/news/2024-05-m… via Medical Xpress

Indeed a fantastic experience with #iPSC engineering The Jackson Laboratory

𝐓𝐡𝐢𝐬 𝐬𝐞𝐫𝐢𝐨𝐮𝐬 𝐛𝐢𝐫𝐭𝐡 𝐝𝐞𝐟𝐞𝐜𝐭 𝐜𝐚𝐧 𝐛𝐞 𝐩𝐫𝐞𝐯𝐞𝐧𝐭𝐞𝐝 𝐰𝐢𝐭𝐡 𝐭𝐚𝐛𝐥𝐞𝐭𝐬 I work and learn in Rajasthan, India and I see babies like this everyday. In India, 𝟑𝟎𝟎 𝐜𝐡𝐢𝐥𝐝𝐫𝐞𝐧 𝐚𝐫𝐞 𝐛𝐨𝐫𝐧 𝐞𝐯𝐞𝐫𝐲𝐝𝐚𝐲 𝐰𝐢𝐭𝐡 𝐬𝐮𝐜𝐡

NICHD scientists & colleagues identified the genetic cause of a rare, infant-onset #neurodegenerative disease. Their work highlights the critical role of the BORC protein complex in nervous system development. Learn more: go.nih.gov/CbYzET3. NIH Intramural #NICHDimpact

Spent a great time at #GRC Cell biology of neuron. The community is so welcoming with fabulous science. Thoroughly enjoyed every session and the outside adventure activities🚴🚣

The amazing work of Thein and Orkin shows how fundamental discoveries and translational medicine can lead to life-saving therapies. CRISPR genome editing for sickle cell disease and β-thalassemia is the first FDA-approved therapy using this technology. shawprize.org/laureates/2024…

A beautiful work elucidating Dynamin structure. Congratulations! Nidhi Kundu and the team

Wonderful experience at #RNASRC FASEB Happy to get connected with the community

I am happy to share that the movie has been selected Nikon Small World Dynamic trafficking of mitochondria and lysosomes | 2024 Small World in Motion Competition | Nikon’s Small World: nikonsmallworld.com/galleries/2024…

Thank you for highlighting our work at Division of Intramural Research (DIR) Highlights NICHD News nichd.nih.gov/about/org/dir/…

Today's Lancet climate and health report presents 56 indicators of health and climate change across FIVE domains. (Download the report for free from the Lancet website). Here is a thread of some of the key findings. #Lancetclimate24 (1)

Thank you NICHD News for the highlight

Latest findings from our lab. Congratulations all.

Excited to present our work in the amazing #Lysosome Subgroup at the American Society for Cell Biology meeting in San Diego! Can't wait to discuss how lysosomal trafficking supports axonal RNA transport. See you there! #CellBiology #Neuroscience

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Highly recommended lab with an amazing group of scientists exploring membrane trafficking in health and disease