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Grateful to have had such an awesome team of lab neighbors! Thanks for welcoming me to join in and learn from you all 🧬

Sarnoff’s 2023-24 Fellows representing at AHA❤️

.Sarah Abramowitz shares work describing the variability in risk predicted by coronary artery disease polygenic risk scores that she is leading as a Sarnoff Foundation Fellow in the lab of Scott Damrauer and Michael Levin. Penn Vascular Surgery PennCVI Penn Cardiology

Our paper "Temporal dynamics of the multi-omic response to endurance exercise training" was just published in nature! nature.com/articles/s4158… This extensive resource on the molecular map of the cross-tissue response to exercise is the result of a massive team effort! 1/

Do the multiple existing PRSs offer reliable individual-level assessment of disease risk❓ 👉48 PRSs for coronary artery disease 👉comparable population-level calibration and discrimination ❗️wide variance in individual-level risk depending on PRS 🔗medrxiv.org/content/10.110…

1/ Excited to share this preprint from all-star Sarnoff Foundation fellow Sarah Abramowitz, studying population- and individual-level performance of coronary artery disease polygenic risk scores, co-mentored with Scott Damrauer.

8/ Our findings raise important practical questions about the clinical implementation of PRS: - When PRS from two different sources disagree, which should we believe? - How should we counsel patients about uncertainty? - Can CAD PRS be individually useful given these limitations?

Our Story is Out - on BioRxiv! Humbled to have worked with such a great team of scientists to investigating how #SGLT2 inhibitors provoke their astounding cardiac benefits.

Are you an MD student interested in research? Would strongly consider applying for the Sarnoff Foundation Fellowship. Scientific immersion with *unparalleled* longitudinal mentorship & exceptional peer network career-long. sarnofffellowship.com My biggest regret in med school was

Excited for these trainee presentations from the lab at AHAMeetings #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!

Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. #AHA24 ja.ma/3Od7BtF

AHA Council on Genomic and Precision Medicine ECC council was honoured to be judging such an incredible group of cardiovascular genetic researchers! 🫀🧬Congratulations to all the speakers - it was truly GPM research with impact and real world applications! Can’t wait for next year! #AHA24 AHAMeetings

Sarnoff at AHA❤️