The textbooks suggest kidney injury in ischemic AKI is due to medullary hypoxia. Our new paper challenges this hypothesis. Our data suggest injury is secondary to RBC tapping and toxic injury from the extravasation of blood. academic.oup.com/function/advan…

Our new paper investigating mechanisms of RBC trapping in ischemic AKI! Function

#AdvanceArticle: "Extravasation of Blood And Blood Toxicity Drives Tubular Injury from RBC Trapping in Ischemic AKI" by McLarnon et al. ow.ly/Y1yT50PLoUp #renal

Our most recent paper investigating the mechanisms of RBC trapping on ischemic injury from the O'Connor lab is out now in the newest issue of Function! Paul O’Connor

For this #FluorescenceFriday, an image showing innervation of the postnatal (P0) kidneys and bladder. Courtesy of postdoc Sarah R. McLarnon and grad student Pierre-Emmannuel N’Guetta.

Fantastic talk from Desmondmoronge on pregnancy after AKI in the Advanced in Renal Physiology session! American Physiological Society

Congrats to Pierre-Emmannuel N’Guetta from Lori O'Brien for receiving the renal recognition award at his first #APS2024 American Physiological Society

Thank you Water and Electrolyte Homeostasis APS for inviting me to share our work at Data Diuresis!

Another great American Physiological Society Summit! So great to catch up with everyone Augusta University #APS2024

View of today's eclipse from NC The University of North Carolina at Chapel Hill Lori O'Brien

Congrats to newly minted PhD Matt Stevenson! A stellar defense and so well deserved. He was the first grad student to join my lab. It was an honor to be his mentor and I look forward to all the amazing accomplishments yet to come in his postdoc and beyond!

Editorial on our recent work in function academic.oup.com/function/advan…

So excited to see Pierre-Emmannuel N’Guetta manuscript officially published! 🎉 He has put in an enormous amount of work to detail kidney innervation Lori O'Brien Comprehensive mapping of sensory and sympathetic innervation of the developing kidney: Cell Reports cell.com/cell-reports/f…

For #FluorescenceFriday sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10.11…

Intermediate mesoderm isn't the sole contributor to nephrons in zebrafish-new manuscript out showing somites are a source of nephron progenitors! Led by Alan Davidson's group. Many fun discussions were had-grateful for the inclusion! nature.com/articles/s4146…

Sharing this excellent review now out from postdoc Sarah McLarnon! Lots of useful info on 3D imaging, quantification of imaging data, and how this has been applied to the kidney. #FluorescenceFriday figure with our own imaging data! sciencedirect.com/science/articl…