Rafael Zubirán (@rzubirans) 's Twitter Profile
Rafael Zubirán

@rzubirans

PostDoc at Lipoprotein Metabolism Laboratory @NIH_NHLBI //
Endocrinology & Internal Medicine at @INCMNSZMX //
Lipidologist // Opinions my own.

ID: 243364384

linkhttps://orcid.org/0000-0003-4274-3585 calendar_today26-01-2011 21:58:05

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Rafael Zubirán (@rzubirans) 's Twitter Profile Photo

What a master class in Apo(a) by Michael Boffa! It's so hard to summarize in a tweet Really interesting data showing how specific mutations on His33 play a major role in OxPL. National Lipid Association #NLASessions

What a master class in Apo(a) by <a href="/MBBoffa/">Michael Boffa</a>!

It's so hard to summarize in a tweet

Really interesting data showing how specific mutations on His33 play a major role in OxPL.

<a href="/nationallipid/">National Lipid Association</a> #NLASessions
Rafael Zubirán (@rzubirans) 's Twitter Profile Photo

A rare picture of Lp(a)! Here, Michael Boffa shows us the thin, fiber-like Apo(a) amino terminus (the "tail") in Cryo-ET! Its variability and mobility make it challenging to get high-resolution 3D reconstruction #NLASessions National Lipid Association

A rare picture of Lp(a)!

Here, <a href="/MBBoffa/">Michael Boffa</a> shows us the thin, fiber-like Apo(a) amino terminus (the "tail") in Cryo-ET! 

Its variability and mobility make it challenging to get high-resolution 3D reconstruction 

#NLASessions <a href="/nationallipid/">National Lipid Association</a>
Thomas Dayspring (@drlipid) 's Twitter Profile Photo

When it rains, it pours - More OBI data. Across 3 phase 3 trials, BROADWAY (obi), BROOKLYN (obi) & TANDEM (obi + ezetimibe), obicetrapib, an oral CETP inhibitor, effectively reduced not only LDL-C, but also Lp(a), especially in those with moderately elevated Lp(a) levels. In

Rafael Zubirán (@rzubirans) 's Twitter Profile Photo

Does HDL-C matter? Anand Rhotagi: Despite low HLD-C being a good predictor of ASCVD, there's been a failure on risk reduction of therapeutics rising HDL-C #NLASessions National Lipid Association #HDL

Does HDL-C matter?

Anand Rhotagi:

Despite low HLD-C being a good predictor of ASCVD, there's been a failure on risk reduction of therapeutics rising HDL-C

#NLASessions <a href="/nationallipid/">National Lipid Association</a> #HDL
Rafael Zubirán (@rzubirans) 's Twitter Profile Photo

Key takeaways from HDL and Diabetes😮 -Diabetes associated changes in HDL are more associated with the U-shaped relationship. This can be largely associated with the particle size shift National Lipid Association Anand Rohatgi #NLASessions

Key takeaways from HDL and Diabetes😮

-Diabetes associated changes in HDL are more associated with the U-shaped relationship.

This can be largely associated with the particle size shift 

<a href="/nationallipid/">National Lipid Association</a> <a href="/dranandrohatgi/">Anand Rohatgi</a> #NLASessions
Rafael Zubirán (@rzubirans) 's Twitter Profile Photo

Take-home message from Anand Rohatgi masterclass! ✉️ HDL are heterogeneous particles, such that cholesterol content does not equal particle concentration or functionality! Measuring functionality or composition for ASVD or Rx remains complicated #NLASessions National Lipid Association

Take-home message from <a href="/dranandrohatgi/">Anand Rohatgi</a> masterclass! ✉️

HDL are heterogeneous particles, such that cholesterol content does not equal particle concentration or functionality! 

Measuring functionality or composition for ASVD or Rx remains complicated
#NLASessions <a href="/nationallipid/">National Lipid Association</a>
Rafael Zubirán (@rzubirans) 's Twitter Profile Photo

If the hypercholesterolemia is not #FH, what is it? Dan Soffer solves this riddle! For this, we should always think about lipids-pheno-clinic-genetic perspective! National Lipid Association #NLASessions

If the hypercholesterolemia is not #FH, what is it?

<a href="/dan_soffer/">Dan Soffer</a> solves this riddle!

For this, we should always think about lipids-pheno-clinic-genetic perspective!

<a href="/nationallipid/">National Lipid Association</a> #NLASessions
Kevin Hall (@kevinh_phd) 's Twitter Profile Photo

Really enjoyed Max Petersen’s talk at #NLASessions on the topic of hypothetical mechanisms of increased LDL cholesterol and ApoB with ketogenic diets. Looking forward to his forthcoming data measuring metabolic fluxes! clinicaltrials.gov/study/NCT06894…

Really enjoyed Max Petersen’s talk at  #NLASessions on the topic of hypothetical mechanisms of increased LDL cholesterol and ApoB with ketogenic diets. Looking forward to his forthcoming data measuring metabolic fluxes! clinicaltrials.gov/study/NCT06894…
Rahul Rege, MD (@rahulrege2) 's Twitter Profile Photo

Fantastic talk by Dr. Ira Goldberg on triglycerides and CVD 👏 Key takeaways: ➡️ Hypertriglyceridemia can increase CVD risk via LPL pathway ➡️ Post-prandial lipemia is an independent risk factor for CVD ➡️ All TRLs are likely atherogenic #NLASessions National Lipid Association

Fantastic talk by Dr. Ira Goldberg on triglycerides and CVD 👏

Key takeaways:
➡️ Hypertriglyceridemia can increase CVD risk via LPL pathway
➡️ Post-prandial lipemia is an independent risk factor for CVD
➡️ All TRLs are likely atherogenic

#NLASessions <a href="/nationallipid/">National Lipid Association</a>
CarlosAguilarSalinas (@caguilarsalinas) 's Twitter Profile Photo

Mi imagen fue usada sin mi autorizacion en un anuncio de un producto que carece de sustento cientifico. Los agonistas GLP1 no pueden ser administrados por via transdermica. Eviten caer en engaños

Georgios Kyriakos (@giorg_kyriakos) 's Twitter Profile Photo

📌 #LDL-C is not the whole story. 🔬 #ApoB-100 shape—not just quantity—may drive plaque risk 🧱 Particle retention 🧬 Aggregation in arterial wall 🔜 We may treat how apoB behaves, not just how much there is 📄 Curr Opin Lipidol 2025 🔗 doi.org/10.1097/MOL.00… #EndoTwitter

📌 #LDL-C is not the whole story.

🔬 #ApoB-100 shape—not just quantity—may drive plaque risk
🧱 Particle retention
🧬 Aggregation in arterial wall

🔜 We may treat how apoB behaves, not just how much there is

📄 Curr Opin Lipidol 2025
🔗 doi.org/10.1097/MOL.00…
#EndoTwitter
Thomas Dayspring (@drlipid) 's Twitter Profile Photo

Excited to see from the NIH team this new modified Sampson equation for a more accurate determination of LDLC. It surpasses all other calculations (Original Sampson, Martin Hopkins, Friedewald) & has high correlation with the gold standard ultracentrifugation method -

Excited to see from the NIH team this new modified Sampson equation for a more accurate determination of LDLC. It surpasses all other calculations (Original Sampson, Martin Hopkins, Friedewald) &amp; has high correlation with the gold standard ultracentrifugation method -
Marcos Gamboa (@markinho_gc) 's Twitter Profile Photo

🔰Función endotelial en pacientes de alto riesgo con ezetimiba. En este estudio de 91 pacientes se encontró que: ✅La función endotelial es mejor en pacientes de alto riesgo con ECVA preexistente tratados con ezetimiba junto con estatinas que en pacientes con estatinas en

🔰Función endotelial en pacientes de alto riesgo con ezetimiba.

En este estudio de 91  pacientes se encontró que:
✅La función endotelial es mejor en pacientes de alto riesgo con ECVA preexistente tratados con ezetimiba junto con estatinas que en pacientes con estatinas en
Marcos Gamboa (@markinho_gc) 's Twitter Profile Photo

🔰Una ecuación de Sampson-NIH modificada con mayor precisión para estimar niveles bajos de C-LDL. 👏Que gran trabajo de Rafael Zubirán y sus colegas, utilizando los resultados de las pruebas del panel lipídico de la Clínica Mayo y el ensayo clínico FOURIER, realizaron una ecuación

🔰Una ecuación de Sampson-NIH modificada con mayor precisión para estimar niveles bajos de C-LDL. 

👏Que gran trabajo de <a href="/RZubiranS/">Rafael Zubirán</a> y sus colegas, utilizando los resultados de las pruebas del panel lipídico de la Clínica Mayo y el ensayo clínico FOURIER, realizaron una ecuación