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Really exciting work on structural studies and engineering of a non-LTR retrotransposon with Max Wilkinson Rhi Macrae and Feng Zhang! Check out the tweetorial below

Nucleases, core components of CRISPR-based genome-editing therapies, can stimulate unwanted immune responses. Scientists have now engineered two CRISPR nucleases to mask them from the immune system, paving the way for safer, more efficient gene therapies. broad.io/Nucleases-CRIS…

Congratulations to Rumya Mirco J. Friedrich Daniel Strebinger Blake Lash Cyrus Biotechnology and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and