If journal styles don’t allow Oxford commas, I’m sending my next three papers to Nature, a predatory journal and a scam publisher

First up: congratulations to all 20 coauthors - Markus Müller & x-less TRP rockstars Michael Schaefer & Konstantin Niemeyer with the heavy lifting; & Robin Bon, Trese Leinders-Zufall, Stefan Raunser, & Bruns/Schwarz/Zufall/Muench labs who brought it home! Molecular Switches photopharmacologypapers here goes 🧵2/n

Usually, photopharmacology tries to optimise photoswitching between a high-activity isomer and a low-activity isomer. This is fine for cell culture because all cells see the same drug concentration. But in vivo, no: ADME-PK, variable distance to blood vessels, animals... 🧵3/n

...mean that even in one target tissue, the dose is different in each cell, and changes over time. So your bio-effect will be completely different, even when applying the same wavelength (same PSS & E/Z ratio), *and differs both in space and in time*

How to escape the concentration-dependency of biological effect? Make a system-internal (intrinsic) compensation method. Self-competitive photoswitches.

For self-competing E&Z isomers, as long as their binding affinities are nearly equal, the overall bioactivity they apply will be purely determined by the E:Z ratio: Which is the *only* parameter you can reliably control in vivo. Just choose a monochromatic illumination λ! 🧵7/n

It's Twitter so much detail has been skipped; but this'll be the last tweet - see paper & Supp Notes for the full story. Thanks so much to all our collaboration community! and please email / post any feedback; looking forward to it! doi.org/m75j 🧵11/11

Also my favourite experiment I the paper...love 'chromodosing'.

A great collaboration between Faculty of Biological Sciences, Prof Val Speirs John Innes Centre using Affimers reagents to target therapeutic agents using virus like particles to breast cancer cells. The Astbury Centre Sophie The National Centre for the 3Rs cell.com/iscience/fullt…

Didn't like the way this @JDVance1 bloke (newly picked as #Trump's running mate) slagged off the UK lately. Looked into him. Not great. Made a parody song inspired by ABBA called "Vance VP" 🎶 Shout out #americast (sarah smith/Anthony Zurcher) & The Rest Is Politics for ℹ️ profiles 👍

Obituary: V. Craig Jordan (1947-2024) pharmacologist who revolutionized breast cancer treatments go.nature.com/3WiB49g

PostDoc Position Now Open! 🎞 Join our High-Speed AFM team in Leeds Application Deadline: 1st September 2024 Apply Online Here: jobs.leeds.ac.uk/EPSPA1117

We're excited to be running our first Anglo-Italian bilateral meeting with chem bio colleagues from the Italian Chemical Society! The meeting will take place from 15-17th December in beautiful Perugia. Abstracts for talks and posters open till 14th Sep. rsc.org/events/detail/…

BREAKING: our friends at Centre for Climate Reporting have been undercover in Project 2025 - the radical plan for a Trump 2nd term. What they’ve found out is remarkable. Learn all about the secretive “second phase” of Project 2025 here 👇

Join me in signing this petition for the UK to rejoin ERASMUS ...David Lammy Ben Judah europeanmovement.co.uk/erasmus-petiti…

A great new paper on TRPC5 channel regulation by the group of Viktoria Vlachova Prague TRP lab. Special congrats to first author Sasha Ptakova. Thanks for allowing me to make a small contribution to this interesting story. LICAMM Ion Channels @Leeds link.springer.com/article/10.100…

Delighted to share our latest preprint where we describe first-in-class DUB #MolecularGlues by Francesca Chandler et al. Another amazing collaboration with Roger Greenberg Professor Francesco Del Galdo and Jo Salvino labs. biorxiv.org/content/10.110…