The ELAN Trial RCT subanalysis ⏰️ Early vs late start of anticoagulations does not seem to have treatment effect heterogeneity on safety outcomes (sICH, recurrent stroke, mRS>3) ✅️ However, 25%⬆️ risk for mRS>3 in people with PH! Roman Rohner #ESOC2024 #VoiceOfStroke

Congratulations to Roman Rohner, Markus Kneihsl and all the ELAN collaborators for all their efforts. Such a wonderful team! The paper has just been published in Circulation !

🧵2/3 🙏 Urs Martin Fischer, Roman Rohner , Jesse Dawson & Markus Kneihsl for leading this international team effort! Stroke Research Center Bern 👏 to Roman Rohner for first #ESOC2024 presentation with simultaneous publication!

Should we start anticoagulation early even in persons w major stroke? ➡️ Our newest paper in JAMA Neurology explores the interaction of early #DOAC therapy and infarct size in the The ELAN Trial Urs Martin Fischer

Can we start direct oral anticoagulants early after ischemic stroke in people with atrial fibrillation AND hemorrhagic transformation? Check our article in CIRCULATION! ⁦⁦⁦Roman Rohner⁩ ⁦Martina Göldlin⁩ ⁦Insel Gruppe⁩ ⁦⁦Universität Bern⁩ ahajournals.org/doi/full/10.11…

❗️A prespecified subanalysis of the The ELAN Trial is here❗️No treatment effect of hemorrhagic transformation on early versus late DOAC initiation among stroke patients with AFib ✅️ Critical data for DOAC timing after stroke 💊 Congrats Roman Rohner & team!

Early start of treatment with blood thinners after stroke & atrial fibrillation reduces risk of recurrent stroke also in large infarcts & haemorrhagic transformation. More: pubmed.ncbi.nlm.nih.gov/38805207// pubmed.ncbi.nlm.nih.gov/38753452/. #InselGruppe #StrokeResearch #Neurology #Neuroradiology

ELAN trial post-hoc analysis: Early DOAC treatment after ischemic strokes was not associated with a higher rate of adverse events, especially sICH, regardless of infarct size group. Persons with major stroke seem to benefit most (OR 0.52 (0.21 to 1.18)). ja.ma/45TrYEj

#ICYMI: ELAN hemorrhagic transformation Roman Rohner Urs Martin Fischer Insel Gruppe; Faculty of Medicine, University of Bern; Universität Bern #AHAJournals

Early anticoagulation in ischaemic stroke patients with haemorrhagic transformation? Stroke Research Center Bern

Join us (Tomas Dobrocky Jürgen Beck) in Singapore (November 14th - 17th) for a comprehensive and interactive session on SIH. All aspects of the disease including a systematic diagnostic work-up, transvenous CSF venous fistula embolization and surgical management will be covered.

Look for the DOTs ⚪️⚫️ Flat-panel non-contrast CT could be enough to indicate which patients will have persistent hypoperfusion (and poor outcome) post-EVT ⬇️⬇️⬇️ jnis.bmj.com/content/early/…

Natural evolution of incomplete reperfusion presented during #SVIN24 ✅️ SVIN Daniel Windecker Petra Cimflova Thomas Meinel David Seiffge Gregoire Boulouis Roman Rohner Kevin JANOT Tomas Dobrocky Michael D Hill Mayank Goyal Eike Piechowiak Urs Martin Fischer Johannes Kaesmacher Stroke Research Center Bern DCNS Calgary