Brilliant interview. Heard many quotes from Michael for the first time here. Personal favorite: the same thing that makes organisms evolvable may also makes them engineerable (speculation).

# Chinese scholar # Old Montreal fire A large fire broke out in a historical building in Old Port District of Montreal, Canada at 5:45 am on Thursday. 6 people remain missing, among which is a promising young Chinese scholar, Dr. An Wu, who came to Montreal for a conference.

Measures of gene constraint like pLI and LOEUF have been hugely useful in human genetics, but they lack power to detect constraint in the shortest 25% of genes. Here, we introduce an empirical Bayes framework (GeneBayes) to solve this problem. biorxiv.org/cgi/content/sh… 1/n

I'm excited about two new papers from our lab for improving estimates of LOF constraint on genes. The most widely-used measures of LOF constraint have no power for the shortest 25% of genes; we show how to do much better using an ML-based prior: x.com/tkyzeng/status…

Our new preprint describes lineage motifs—over-represented patterns of cell fates on lineage trees. For us biologists, motifs reveal cell fate control programs. For developing tissues, they could set, modulate, or evolve cell fate composition. biorxiv.org/lookup/content…

The Gladstone Institutes UC San Francisco Genomic Immunology Institute has an exciting new position open for a lead scientist to manage a preclinical team to benchmark, optimize, and compete innovative new gene-engineered T cell therapies for cancer + beyond: gladstone.wd5.myworkdayjobs.com/en-US/careers/…

Check out this cool paper!

Big news! My PhD work, exploring how positive feedback mediates cell fates through bistability, is now published! It's a work we're profoundly proud of. Eagerly awaiting your thoughts and insights. Do give it a read! doi.org/10.1016/j.cub.…

Honored to be selected as a Damon Runyon Fellow! Thank you Damon Runyon Cancer Research Foundation, Connie and Bob Lurie for your strong support. Also grateful for the backing from my current labs @MarsonLab Jonathan Pritchard and former colleges ElowitzLab, Jordi Garcia Ojalvo, Justin Bois, Matt Thomson & others.

Check out this awesome story on how functional genomics methods are used to dissect gene networks in gdTcell-cancer cell interactions. Congrats Murad Mamedov and team!

Check out this new story from @MarsonLab led by Blaeschke Lab

I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…

Excited to share a milestone in our forward genetics developments! Today in nature we report massive mutagenesis screening in T cells with base editors, increasing resolution from genes to nucleotides nature.com/articles/s4158… A @MarsonLab story with my dear friend Carl Ward 1/10

Just posted a preprint on our new spatial genomic recording system, baseMEMOIR. biorxiv.org/content/10.110… Motivation: Cells divide, differentiate, and migrate to form exquisitely organized tissues. Reconstructing the dynamic histories of individual cells, including their lineage

Nice compact and simple system for reducing transgene expression heterogeneity. Improved imaging data look amazing. Congrats Rongrong, Mike and teams!

Incredible three days of getting to know the awesome new science and community at the frontier of profiling and programming biological systems.

Elegant design and incredible engineering feat. Has so much potential to combine with other cancer therapeutic modalities. Congrats team!