After a long journey, it is finally there: Male #malaria parasites (#Plasmodium) need a highly divergent Arp2/3 complex to take their genome along when they want to infect a #mosquito. Have a look at the preprint here: biorxiv.org/content/10.110… #Arp23 #actin #mitosis

It appears #NIAID will shutter the genome data base we all use daily. This strikes me as a significant mistake that may well endanger much of our global progress. British Society for Parasitology Aust Soc for Para ASTMH Trends in Parasitology ASP-Parasitologists parasitesrule PEERs in Parasitology (PiP)

Congrats to Rouaa BC and all the authors for putting another piece into the rhoptry disharge puzzle! 👏🏼🧩 Yet another successful collaboration with Yi-Wei Chang ! 🤝🏼 journals.plos.org/plosbiology/ar…

🚨Preprint 🚨 RNG2 tethers the conoid to the apical polar ring in Toxoplasma gondii: a key mechanism in parasite motility and invasion biorxiv.org/content/10.110…

Congrats to Sanchez Syrian and all the authors involved in the paper describing a novel protein involved in apicoplast homeostasis and parasite growth! 👏🦠🐈‍⬛ biorxiv.org/content/10.110…

#Apicomplexans need specialized structures to invade host cells & replicate. Peter Back Gary Ward @ToxInLA &co show that alveolin protein IMC6 is crucial for maintaining cellular morphology, invasion & successful replication in #Toxoplasma #PLOSBiology plos.io/3BgjxaE

Apicomplexan #parasite division: Mathieu Gissot &co show that the #phosphatase TgPP1 in #Toxoplasma regulates the #CellCycle & amylopectin accumulation by dephosphorylating inner membrane complex & starch-binding domain proteins #PLOSBiology plos.io/3XwMYgj

Extremely proud to see this beautiful collaboration with Yi-Wei Chang lab published. Thanks to all the people involved in this work. #ExM #CryoET pnas.org/doi/10.1073/pn…

🚨 New publication out: Architecture of the Toxoplasma gondii apical polar ring and its role in gliding motility and invasion 🧫🐈‍⬛ Read more pnas.org/doi/10.1073/pn…

In this article, a repertoire of apical polar ring proteins was studied and assigned to the different APR layers. Among them, APR2 contributed to parasite's motility and invasion and its depletion caused destabilisation of the APR middle layer and F-actin leakage to the cytosol.

Thanks to the wonderful collaboration with Yi-Wei Chang 🤝 and congratulations to Bingjian Ren, Romuald Haase and all the authors involved! 🔬❄️🎉

You want to know more about iron-sulfur cluster biogenesis in Apicomplexa? Have a look at our latest review, just out in the "Biogenesis and function of FeS proteins" special issue of @BBAjournals BBA Mol Cell Research: authors.elsevier.com/a/1k7COc5IDqQUG

Targeted CRISPR Screens Reveal Genes Essential for Cryptosporidium Survival in the Host Intestine (full thread in the other place!) Lucy Watson biorxiv.org/content/10.110…

How does #Toxoplasma gondii move? UNIGE_en scientists reveal apical polar ring & conoid as key players controlling actin flow, crucial for motility & invasion Full bit.ly/4i33Tk3 Summary bit.ly/4i9Zg7V By Romuald Haase & Bingjian Ren Soldati Lab MIMOL_UNIGE

Mitochondria are the powerhouse of the cell, producing essential energy for life 🏭⚙️. To synthesize the proteins for this process, mitochondria have mitoribosomes. But, how do the mitoribosomes from Alveolates assemble? 🧵 nature.com/articles/s4146…

Delighted to share our study on a major Toxoplasma virulence factor that prevents lytic host cell death. Many thanks to LabEx ParaFrap for support, constructive reviews and all labs involved: Melissa Lodoen, Hiba El Hajj, Mathieu Gissot, Karine Le Roch Link : rdcu.be/d6m3G

Remember learning that #ribosomes are made of 1 large subunit RNA + 1 small subunit RNA? Well, some cells defy this rule, and the most extreme case is #Toxoplasma which makes its mitoribosome from >50 RNA pieces! Wanna know how? Read the next comments.

🚨New paper out! 🚨 The apicoplast is an essential plastid retaining many crucial metabolic pathways 🦠🏭 However, bypassing all of them makes the apicoplast dispensable! nature.com/articles/s4146…

Thrilled to share my first paper, now out in Nature Microbiology! Huge thanks to my amazing supervisor HAKIMI Mohamed-Ali and everyone who contributed to this work! nature.com/articles/s4156…

Unlocking new understanding of Plasmodium sporozoite biology with expansion microscopy biorxiv.org/content/10.110… #biorxiv_micrbio