Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders biorxiv.org/content/10.110… #biorxiv_bioinfo

🚀 AlphaFold3's ipSAE_min is the new default for de novo protein binder triage. Across 3,766 designs/15 targets, ipSAE_min had +1.4× AP vs ipAE (add ΔG/ΔSASA or shape complementarity to boost precision). 🔥 Interface‑focused confidence + physics is overtaking

My practical takeaways: 1. Prioritize by AF3 ipSAE_min; consider thresholds like ipSAE_min > 0.61, or use interaction filters such as ipSAE_min × (ΔG/ΔSASA) < −1.5, or LIS × shape‑complementarity > 0.42. 2. Pre‑filter designs with shape‑complementarity > 0.62 and optionally

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enshittification | noun | when a digital platform is made worse for users, in order to increase profits

So this was a nice thing that happened to me today. 😀

Honored to receive the 2026 ASBMB Ruth Kirschstein Award for Maximizing Access in Science. Research Trainee Affairs at Penn Medicine Univ. of Pennsylvania Department of Cancer Biology.

Pay attention to James Talarico. He’s 36. He’s social media savvy. He communicates with all audiences calmly. He talks about issues not many Democrats talk about. He’s a star & he’s the future of our party—& he’s now running for Senate in TX. Watch this.

ACIP Is Now Obsolete "the meeting devolved chaotically: a decision passed on Thurs by members who misunderstood the vote had to be reversed on Fri meanwhile, one panelist on a "hot mic" called another panelist an "idiot". 😳 You can't make this up. medpagetoday.com/opinion/second…

Secretary of War Pete Hegseth If you are willing to defend the slaughter of innocent civilians in the past, you are perfectly capable of ordering that in the present. You are a danger to this country and don't deserve your position. You're just a drunk sociopath.

WOW! ICE Nazis in Chicago tried to kidnap this food delivery worker but the guy was too fast for those ICE agents! 👏🏽🔥

Markwayne Mullin The White House With his great sense of humor, 🍊🫡👔Donnie will definitely appreciate this snippet of the @Whitehouse Hall-O-Fame upcoming Halloween bash - where legends come to life - circa October 2025

all ideal place pictures reveal that everybody hates cars and probably don't even realise it