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Women are 4-times more likely to have autoimmune diseases than men. Why is this? From Dou et al. in Cell, today In females, the second X chromosome is silenced by a long non-coding RNA, called Xist (pronounced 'exist') - males don't express Xist Xist, together with almost

BIG: #Tirzepatide, which is sold commercially as #Mounjaro or #Zepbound, succeeded in a Phase 2 test as a treatment for the fatty liver disease #MASH: 74% of treated patients were free of MASH after 52 weeks vs 13% of the placebo group. statnews.com/2024/02/06/eli… via STAT

So much fun presenting our work on the methylome of patients with PSC and IgG4-related cholangitis at ECCO’24! Highlights: 🧬 SNPs in the HLA region drive methylation in PSC-UC ⏰ Patients with IgG4-related cholangitis have epigenetic age acceleration #livertwitter #IBD

What is PSC? On #RareDiseaseDay we're sharing this short video about PSC. Do your friends, colleagues and networks know what PSC is? Share this video to raise awareness about PSC, a rare immune-mediated liver disease that affects the bile ducts and liver. bit.ly/3wufk0T

“In a historic move toward hope and healing, an international group of clinicians has declared April 4 as IgG4-RD Awareness Day at the Fifth International Symposium on IgG4-Related Disease in Milan.” Thanks to Alliance for Patient Access for sharing the message: shorturl.at/eilQ6 💙

I was quite surprised by the invitation, but I’m really happy to be the Featured Researcher of Translational Gastroenterology & Liver Unit (TGLU) in April and to share some of the work we’ve been doing 😁 expmedndm.ox.ac.uk/tgu/about-us/f…

We're committed to funding £1m in research by 2030, turning ideas into reality and working towards finding effective treatments and a cure for PSC. Our Research Training Fellowship application deadline is 1st June ➡️ buff.ly/3UYe922 #LetsBeatPSC #PSCResearch #Mission2030

These are marvellous results! 87% (!!!) reduction in the risk of IgG4-RD flare compared to placebo! Looking forward to read the entire paper.

Our June Ask the Expert session is now available to watch or rewatch on our PSCSupportOnline YourTube channel. This was another popular session where we were joined by Dr Emma Culver who shared PSC research updates from the International Liver Congress. ➡️ buff.ly/4bpPFVZ

New study shows that whether you’re a weekend warrior or regularly active, getting more moderate-to-vigorous physical activity (MVPA) reduces the risk of developing #MASLD. Just 150+ min/week of MVPA can make a big difference! #ExerciseIsMedicine bmcmedicine.biomedcentral.com/articles/10.11…

As they probably should 😂

Had an amazing time at UEG Week 2024 my_UEG and even got the best moderated poster presentation award for our work on IgG4-related cholangitis and pancreatitis! IgG4ward Credits to Dr Emma Culver for the photos and the mentorship!

We are giving away a signed (!) copy of Peng Ding's wonderful book on #causal #inference. Re-post this and follow me by October 27 for a chance to win. More details on the book here: routledge.com/A-First-Course… #Statistics CRC Press Data Science, Stats, and Math Books not affiliated with X.

First successful grant application! Unbelievably grateful for the opportunity PSC Support ! Could not have done it without the support of my co-applicants. Big shoutout to Alex Noble who introduced me to the fantastic world of epigenetics!

Looking forward to this Information Day!

Investigators in liver disease take note: Disease-specific instruments are more responsive to small but important changes in health status. If interested in #QualityofLife in patients which chronic #LiverDisease this is the instrument to use. pubmed.ncbi.nlm.nih.gov/10403745/

Incredibly happy for this opportunity and very excited to start the project!

Today we start the 4-day Regression Modeling Strategies course. Always energized by the bright &motivated participants. Partnering a PhD biostatistician (me) w/a PhD epidemiologist (Drew Levy) creates a nice combination of viewpoints. #rmscourse hbiostat.org/rms

So incredibly proud of you and your work! Keep shining and changing lives ✨