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Unbelievably rapid identification of the putative hepatotoxin. We should have heightened alert for future cases from plant base proteins as these are more widely used in lieu of animal protein. Really enjoyed the presentations!! Michigan Hepatology Liver Fellow Network AASLD

Using ipsc derived hepatocytes should overcome a lot of prior limitations of primary cells. MPs with flow enhance function and get us closer to in Vivo environment. Really excited to be a part of this cutting edge work !!! Michigan Hepatology Liver Fellow Network AASLD EdinClinTox

We can move the field forward and help our patients in their journey to improved liver health by using FDA approved meds for AUD. Start low and go slow and use alcohol biomarkers to guide the way…..

My sense is that this is the ultimate team sport. PCP’s are in the frontline of the 20-30% of population with masld. It is critical for all practitioners to know about biomarkers for. Risk stratification so that high risk can be triaged for the growing # of treatments

1st case of Tirzepatide DILI !!! GLP-1 agonist--> wt loss & improve MASLD but ? hepatic AE. 64 y.o. M hepatitis + jaundice at wk 6 of Rx. Bx--> patchy centrilob injury, duct rxn @Livertox @Liverfellow Michigan Hepatology Lily Dara 10.1016/j.cgh.2024.06.025

COVID Vaccines & DILI? 16 cases of mRNA Vaccines acute hep at 16 d. 75% hepatocellular, 37% jaundice; 88% resolve by mon 6; steroids in 37%. ↑ERAP-1/ERAP-2 variants. Michigan Hepatology Bruce Sanderson PMID: 38314748 DOI: 10.14309/ajg.0000000000002702

HDS Botanicals in the US: > 15 million Americans take potentially hepatotoxic HDS botanicals every Day ! Most self-initiated to “Boost Immunity or Energy” doi:10.1001/jamanetworkopen.2024.25822 Michigan Hepatology LiverTox Michigan Medicine

Very excited about this new high thru-put platform to accelerate DILI research. Viability to 28d will provide improved simulation of human DILI and co-factors. GO BLUE !!! Liver Fellow Network LiverTweet EdinClinTox Einar S. Björnsson

Important study demonstrating the need for more accurate labeling of hds products.Liver Fellow Network Michigan Hepatology EdinClinTox

The Dream Team! DILIN Steering Committee Face to Face Meeting in Washington DC- October 7, 2024 Shaping the future in DILI research and prevention

An amazing group of innovative and savvy investigators . Very grateful to be a part of this group leading the way in DILI research and clinical care !! Michigan Hepatology Liver Fellow Network EdinClinTox Einar S. Björnsson

Looking forward to getting this published and creating a website for colleagues to use LiverTox Liver Fellow Network Michigan Hepatology Michigan Medicine

Kudos to Robert Fontana and jonnysexton for pulling off a very successful Hepatotoxicity SIG session on organoids at #tlm2024! Cutting edge tools to study liver disease and DILI! AASLD

HLO’s (organoids) are really powerful tools to study the pathogenesis and help develop treatment of Dili, viral hepatitis and toxin mediated liver injury EdinClinTox Liver Fellow Network Michigan Medicine Michigan Hepatology

HUGE SUCCESS !! 6 MI GI fellowships made 15th Annual Michigan DILIN dinner on 1/22 great time for all. Cool stuff on ICI's, HSV & Bactrim DILI. Keep the cases coming. Michigan Medicine LiverTox Liver Fellow Network Michigan Hepatology LiverTweet

Thx so much for warm hospitality & weather at Loma linda liver grand rounds. Great facility &program. Fun to catch up with Andy w. And Mina !!! LiverTox Michigan Medicine

MASLD is no laughing matter- or is it?? Great presentations today at 2nd annual UM debate LiverTox Liver Fellow Network Michigan Medicine Lily Dara

Had a great time catching up with the growing clan of GI alumni in San Diego !! Go Blue !@UMichGIHep Liver Fellow Network LiverTox Michigan Medicine

I learned a lot from my esteemed colleagues. Alf patient outcomes continue to improve with better diagnostics, early CTRRT, less blood products.and more thoughtful use of txp. It takes a village for rare diseases!! Liver Fellow Network UMichGIHep-Fellowship LiverTox

Prior Wt loss surgery associated with increase risk of APAP ALF/ ALI. Check it out!!! Study from the ALFSG bit.ly/43ITy7x Michigan Medicine Liver Fellow Network LiverTox Michigan Hepatology