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Fantastic job by all of the fellows !!! Really enjoyed cases, THE DEBATE, & having dinner with everyone! Lily Dara Michigan Hepatology LiverTox Liver Fellow Network

Great selection & presentation of cases !!! Beware of those HDS products including Turmeric spiked with peperine !!! LiverTox Jasmohan Bajaj

My pleasure !!! Really great cases with lots of clinical pearls - looking forward to next year !! Bob

Read the paper by Axel Wester et al on "Glucagon-like peptide-1 receptor agonists + risk of major adverse liver outcomes in patients with chronic liver disease + type 2 diabetes" via bit.ly/47OtXsQ @hanneshagstrom @yingshang1 Anthony Matthews Karolinska Institutet #GLP1

Important retrospective study that suggest that GLP-1 agonists may have benefit in improving hepatic morbidity and mortality Jasmohan Bajaj Michigan Hepatology Liver Fellow Network

Can we⬇️#sarcopenia with a capsule in #cirrhosis ? Yes! #gutmuscleaxis #gutbrainaxis In #RIVET RCT w #rifamycinSVMMX,we found 🔑⬆️handgrip,💪mass & physical well-being How? Altered #microbiota function w⬆️butyrate, ⬆️active #androgens &⬇️#ammonia Read⤵️ journals.lww.com/hepcomm/fullte…

🥇🥇Standing ROOM Only in ANN ARBOR !! 1st Annual GI Fellows March MASLD Madness. Great fun, presentations, and spirited barbs. Coveted trophies and consolation prizes for debaters. Great Job Abhi et al! GO BLUE! UMichGIHep-Fellowship Michigan Hepatology Liver Fellow Network LiverTox AASLD

Kudos to my GI colleagues!! Kim Turgeon and Elena Stoffel inducted into CLINICAL EXCELLENCE SOCIETY- overdue recognition of Outstanding Patient Care!!! CONGRATULATIONS 🥇🏆👋👋

Congratulations Scott on this prestigious honor !! Well deserved !

Incredibly saddened to learn about Steve’s untimely passing. He was a dynamo of energy, talent and passion for patients with liver disease and to help the medical community with best practices and evidence based medicine. RIP. Michigan Hepatology LiverTox Liver Fellow Network

Parallel trends in DILIN & ALFSG over past 20 yrs. Decrease in isoniazid, nitrofurantoin and anti- convulsant HTX but definite increase in HDS . Value of nih networks to inform the medical community!!!! We would never have seen this at single sites- the power of teamwork !!

Way to go FRED!! Leading the way in gene therapy for Wilson’s disease data look very promising!! Liver Fellow Network LiverTox AASLD

Unbelievably rapid identification of the putative hepatotoxin. We should have heightened alert for future cases from plant base proteins as these are more widely used in lieu of animal protein. Really enjoyed the presentations!! Michigan Hepatology Liver Fellow Network AASLD

Using ipsc derived hepatocytes should overcome a lot of prior limitations of primary cells. MPs with flow enhance function and get us closer to in Vivo environment. Really excited to be a part of this cutting edge work !!! Michigan Hepatology Liver Fellow Network AASLD EdinClinTox

We can move the field forward and help our patients in their journey to improved liver health by using FDA approved meds for AUD. Start low and go slow and use alcohol biomarkers to guide the way…..

My sense is that this is the ultimate team sport. PCP’s are in the frontline of the 20-30% of population with masld. It is critical for all practitioners to know about biomarkers for. Risk stratification so that high risk can be triaged for the growing # of treatments

1st case of Tirzepatide DILI !!! GLP-1 agonist--> wt loss & improve MASLD but ? hepatic AE. 64 y.o. M hepatitis + jaundice at wk 6 of Rx. Bx--> patchy centrilob injury, duct rxn @Livertox @Liverfellow Michigan Hepatology Lily Dara 10.1016/j.cgh.2024.06.025

COVID Vaccines & DILI? 16 cases of mRNA Vaccines acute hep at 16 d. 75% hepatocellular, 37% jaundice; 88% resolve by mon 6; steroids in 37%. ↑ERAP-1/ERAP-2 variants. Michigan Hepatology Bruce Sanderson PMID: 38314748 DOI: 10.14309/ajg.0000000000002702

HDS Botanicals in the US: > 15 million Americans take potentially hepatotoxic HDS botanicals every Day ! Most self-initiated to “Boost Immunity or Energy” doi:10.1001/jamanetworkopen.2024.25822 Michigan Hepatology LiverTox Michigan Medicine

Very excited about this new high thru-put platform to accelerate DILI research. Viability to 28d will provide improved simulation of human DILI and co-factors. GO BLUE !!! Liver Fellow Network LiverTweet EdinClinTox Einar S. Björnsson