Really cool finding: a novel enzymatic function of histones. Congrats, Narsis Attar, MD, PhD et al!

Reading while I drink my morning coffee: nejm.org/doi/full/10.10… (Although would be a high bar for the data to convince me to stop drinking coffee!) NEJM

Really careful work to answer the long unanswered question: how is glucose sensed by the nutrient sensing pathway upstream of the Rags-mTORC1. Spoiler: it’s not glucose itself! Congrats José Miguel Orozco! nature.com/articles/s4225…

Great perspective by Mark Leick in NEJM! It was a pleasure to work on a team with Mark at the beginning of the pandemic — Mark (an onc fellow) worked as a medicine resident due to the surge... and didn’t miss a beat when introducing himself as a “JAR” instead of a fellow!

To all the liver lovers, here is an amazing opportunity to study super interesting questions about liver regeneration in Kristin Knouse’s lab at Whitehead Institute!

Looking forward to presenting this paper at Ginty lab journal club today... special thanks to Jatin M. Vyas, MD, PhD for sending me the paper literally minutes after it came out! nature.com/articles/s4158…

How we celebrate lab birthdays these days...

Really nice work from Kendall David M. Sabatini et al using CRISPR screens (instead of the classic IP/MS) to find mTORC1 regulators! Congrats Kendall!

Novel work from the Caroline Sokol MDPhD lab elucidating the role of sensory neurons triggering dendritic cell migration in the allergic response. Congrats Caroline Sokol MDPhD et al! Can’t wait to see what will follow

Check out Seungwon (Sebastian) Choi 최승원’s beautiful work identifying two parallel ascending pathways in the anterolateral tract that are necessary for conveying tactile and noxious information from the periphery to the lateral parabrachial nucleus. It was such a pleasure to contribute to this!

On my first day at the Whitehead, Angelika gave me her unvarnished view of me: I needed to be baptized and stop working on rapamycin. From that day on I was in awe of her honesty and brilliance and humor. She was our greatest scientist and human. Rest in peace my dear friend.

Beautiful work from Hank Adelmann et al introducing a new technique for rapidly purifying melanosomes and an example of the amazing things you can discover with it! Looking forward to seeing what else you can find in melanosomes...

Missing my family today, but so grateful for my lab family ❤️ HarvardBrainScience

Thanks David M. Sabatini! It was an honor to follow in the footsteps of so many talented female grad students... and to pass the torch along to the next generation!

As always, Robert Saxton doing beautiful structural work and then taking insights from the structure to stimulate likely important clinical therapies in the future. Congrats, Bobby! Excited to see what you’ll do next...

Super interesting work from Allison McCann on vaccine eligibility. I am ready for the day when everyone is eligible.

Here is some COVID vaccine allergy knowledge from my favorite allergist (and also sister!) Anna Wolfson, MD news.wttw.com/2021/05/10/vac…

New content online: A prime role for PIEZO2 in DRG neurons in mechanosensation in the gut dlvr.it/SvPNSZ