Rittle Lab (@rittlelab) 's Twitter Profile
Rittle Lab

@rittlelab

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linkhttp://www.rittlelab.com calendar_today12-08-2018 19:02:16

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(1/4) “Though an essential trace element, manganese is generally accorded little importance in biology other than as a cofactor for some free radical detoxifying enzymes and in the photosynthetic photosystem II.” -David Kehres

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(3/4) The absence of natural manganese-dependent hydroxylases implies that this metal ion is either not competent to activate C-H bonds, or that such enzymes have eluded discovery. Borovik Lab Goldberg Lab

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(4/4) biorxiv.org/cgi/content/sh… We report here the first Mn-dependent hydroxylase known in biology. Lots of really fun crystallography and spectroscopy in there. More Mn enzymes will follow. But for now: Well done, Magan Powell.

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Our next exploration into reactive phosphinimide transition metal complexes is a mononuclear Cr(II) complex capable of multielectron reductions of a variety of small molecules. Check it out here! chemrxiv.org/engage/chemrxi… Chuck Winslow

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The second chapter of our Chromium chemistry can be read here: chemrxiv.org/engage/chemrxi… An exceedingly rare example of a 4-electron oxidative addition. Great job Paul!

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We've got something for everyone here: bioinformatics, enzymology, crystallography, spectroscopy, and of course, manganese. Great work Chang, Magan, and Guodong! R. David Britt chemrxiv.org/engage/chemrxi…

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Here Sarah, Chang and George report a new family of diiron hydroxylases that function on diterpenoids found throughout the biosphere. (?/?) chemrxiv.org/engage/chemrxi…

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Check out our latest collaborative efforts with the R. David Britt and MTGreen labs to investigate dioxygen activation by a trinuclear iron compound. Great job HB, Nick and team! chemrxiv.org/engage/chemrxi…