Ever wondered if CRP is a good triage test for TB among a symptomatic population in a high transmission setting? Read on below! TLDR: it looks pretty good and is relatively cheap, with POC assays available - so should be the benchmark for newer assays to beat. Time for an RCT!

Enjoyed giving my first in-person talk since 2019… Thanks for inviting me Chris Chiu and for the great discussion #FIS21

Enjoyed writing this with Maarten van Smeden. What does this all mean for the application of QCOVID in practice? Read on below for our thoughts…

Thank you to investigators worldwide who have validated the 4C Mortality and Deterioration models for #COVID19 -fantastic team approach to prediction modelling. Here is our own further validation in 76K UK patients admitted to hospital with #COVID #rstats thorax.bmj.com/content/early/…

The Omicron variant is spreading very fast globally. It is already dominant in London, but likely at high frequency in many other places in the world that do not have a viral surveillance infrastructure comparable to that of the UK. 1/ x.com/theosanderson/…

No better way to start 2022 than revel in earlier optimism of being in a new phase of pandemic. Further variants always a likelihood, however, Omicron in SA hopefully a prelude to what to expect moving ahead- death rate only 13% compared to delta wave.

Another, new, update thread on where the NHS is up to, given fast moving situation. Draws on latest performance and covid data and recent intelligence from trust CEOs. Also looks at staff absences, access to tests and NHS work to create extra surge capacity. Happy New Year! 1/25

Work UCLH on Fungal Disease in our large haem cohort bit.ly/3fF3uW0 Ideal someone interested data-science Infectious Diseases/Haematology

When people ask what a collapse of the NHS would look like, it's this, it's already here. It's not going to be bricked up hospitals and no one answering 999, it's going to be lowering standards and rationing care. Acknowledging we can no longer help everyone who calls.

“Preventive therapy as a means to curb the TB epidemic” – at this Friday’s UCL/LSHTM World TB Day Symposium - Session 4. With Gavin Churchyard, Rishi Gupta, Finn McQuaid. Hybrid event. ucl.ac.uk/tb/world-tb-day Gavin Churchyard Rishi Gupta Finn McQuaid LSHTM TB Centre UCL Global Health

1/ The COVID-OUT trial showed that the incidence of long COVID was reduced with a 14 day course of metformin compared to placebo (6.3% v 10.4%). So should we be prescribing metformin to patients with newly diagnosed COVID? Some thoughts...🧵 thelancet.com/journals/lanin…

This was the slide for me from @KatharinaKranz4 inaugural lecture London School of Hygiene & Tropical Medicine - collaboration as the mechanism to expand both breadth & depth of research. Wonderful & inspiring.

🚨Are viruses a more important exacerbation trigger in bronchiectasis than we realised? Our recently funded Medical Research Council experimental medicine grant will use human viral challenge to elucidate exacerbation immunopathogenesis Imperial Department of Infectious Disease NHLI CBRB Imperial School of Public Health

Out now and co-written with colleagues THRU_ZIM LSHTM TB Centre & Zimbabwe NTP. We can (and must!) do better for households affected by TB by moving beyond a narrow focus on TB and nothing else. The Lancet Global Health thelancet.com/journals/langl…

Well-characterised longitudinal cohorts and generation of IPDs are pivotal to understand the movement of people across the spectrum of TB. Find out more 👇👇 @KatharinaKranz4 Claire Calderwood Celso Khosa Rishi Gupta thelancet.com/journals/lanmi…

Our ThoraxBMJ meta-analysis of cumulative silica exposure + silicosis risk out today! TLDR; current UK permissible limits => high risks of silicosis esp in miners ⛏️. Halving limits would significantly reduce risk NHLI Imperial Medicine Medical Research Council Jo Feary Jo Szram 💙

"Methods for Evaluating Models, Tests & Biomarkers" Save the date for the MEMTAB 2025 conference! 29th April - 1st May 2025 University of Birmingham, UK. Abstract submission opens in next fortnight Initial details & past meetings: memtab.org

TB-affected households face multiple health risks beyond TB, like HIV, malnutrition, and NCDs. In our study across 3 African countries, 1 in 2 had a TB risk factor & 1 in 5 experienced multimorbidity. Claire Calderwood journals.plos.org/plosmedicine/a…

In this correspondence in The Lancet Respiratory Medicine we highlight the challenges of inferring TB preventive therapy effectiveness from observational studies: thelancet.com/journals/lanre… A product of the September TB Journal Club... great forum for discussion James Greenan-Barrett Mahdad Noursadeghi

Great presentation by Leyla Larsson at the #tbscience session The Union Conference on the charactization of the spectrum of #TB using data from ERASE-TB Bravo!! @KatharinaKranz4 The Union