Cocainebear was a fantastic choice yesterday. I would love your suggestions for a movie tonight. Genre; the kind of movie your wife roles her eyes about, but not as bad as you might expect.

Huge FOMO right now, luckily Femke Feringa will be representing our efforts on Apoe4 & glial (immuno)metabolism. Who are the other speakers Holly!?

This looks great! Looking forward to speak there, among many other and beter scientist!!

The existing HIV drug #Efavirenz may also be effective for patients with #Alzheimer's disease. The clinical trial to test this will start this fall at Amsterdam UMC, led by dr. rik van der kant. The study is still seeking participants. Read more ⬇️ amsterdamumc.org/en/research/in…

A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states Nature Neuroscience nature.com/articles/s4159…

🚨New Paper Alert🚨Explore our latest work on the Lysosomal BrainAtlas, now available on bioRxiv! This comprehensive resource maps lysosomal proteins in specific brain cell types and identifies SLC45A1 as a novel neuron-specific lysosomal sugar transporter doi.org/10.1101/2024.1…

I stole this from a tweet I saw a day or two ago, but now can’t find. Anyway, it’s on my office door now.

We are going to have so much fun!

Everything I love. Brain cells, lysosomes and Alessandro Ori

Can’t fail to notice how good the Netherlands does in these calls! 8/10 projects have a Dutch participant. Including a wonderful AD project lead by Betty Tijms , congrats!!

Excited to share this (my first single-authored) #lipidtime minireview!🎉 I’ve synthesized all the insights from >5 years of experiments (including some unpublished work) to explore the dynamic regulatory network of phosphatidic acid (PA) metabolism ✅🔗👇 doi.org/10.1042/BST202…

Neurons and astrocytes have distinct organelle signatures and responses to stress biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Preprint alert! Led by Shannon Rhoads, we used 🌈🔬 to elucidate the #organelle signatures of #neurons and #astrocytes at baseline and in response to neurodegenerative-disease associated stressors. See Shannon's awesome tweetorial below! biorxiv.org/content/10.110…

Extremely nice #preview of our own work, as well as of the other MS-in-a-dish paper from VFossati (she, her) by Jerome Mertens and team

Or that the effect of APP on Tau is not really mediated by Amyloid beta…. but by other APP fragments that are similarly produced in this mice, but not removed by the antibody.

It's time to register for #APOE24 !!! (the most interesting genotype, by the way) See you all in Miami!!! 👩‍🔬🌴🏖️🇨🇺 ApoE Discoveries Courtney Kloske, PhD Igor Camargo Fontana Claire Sexton Josh Morganti Shannon Macauley

I am recruiting for 2 posts to join our FTD research! A research assistant or postdoc working on PET and coordination of a new study: jobs.cam.ac.uk/job/49140/ A biostatistician to work on blood-based markers in ONFIRE: jobs.cam.ac.uk/job/49134/ Deadline 8th Dec - share widely!

Another great session line-up for SCMND2025! Sally Cowley, Young-Pearse Lab rik van der kant & Dr Hazel Hall-Roberts See the rest of our speakers, submit your abstract, and register over on scmnd.com UK Dementia Research Institute Oxford Neuroscience Cardiff University Neuroscience & Mental Health Harvard Medical School Vrije Universiteit Amsterdam (inactief)

I’m also done with this place. See you on the flipside!