Our latest🔺research hot off the press. A pleasure, as always, working with @Armstrong_CBio Liang Wu Jamie Blaza ProfG using our new YSBL cryo-EM facility. Structure Protein Data Bank cell.com/structure/full…

Deadline this week! Please share widely! Brilliant opportunity and a great place to work.

The enzyme MYORG, linked to primary familial brain #calcification, was presumed to be an α-glucosidase. Richard Meek &co LaboratoryChemicalGlycobiology describe the structure of dimeric MYORG, surprisingly revealing it to be a specialized α-galactosidase #PLOSBiology plos.io/3R03K1X

Super excited to share this PhD opportunity in my lab to study carbohydrate-active enzymes in plant signalling networks. With @mjtplantbiology and Andy Pickford. South Coast Biosciences DTP program. More details: southcoastbiosciencesdtp.ac.uk/project/decodi…

I’m a bit late posting, but thrilled to see this highly-collaborative project from my PhD finally in print Angewandte Chemie. Our goal was to find new binders/inhibitors of OGT and, oh boy, do they ever inhibit! #Glycotime doi.org/10.1002/anie.2…

Booking is up and running! rsc.org/events/detail/…

In other news, I have an opening for a PDRA in my group Rosalind Franklin Institute opportunities.rfi.ac.uk/vacancy/pdra-i… Job is to apply (bio)chemical protein labelling methods to aid cryo-EM and ET imaging. End goal is to see #glycotime machinery working inside cells. Contact me for details. Pls share

1/9: #ScienceNews Alert! Recent studies shed light on how pathogenic bacteria use enzymes to disable our immune system. Streptococcus pyogenes secretes two enzymes, IdeS and EndoS, which specifically deactivate antibodies. nature.com/articles/s4146…

And now in its published form: rdcu.be/dafje Have a look if you are interested in how mycobacteria cleave their D-arabinan, thread below explains the pre-print.

Identification of D-arabinan-degrading enzymes in mycobacteria Patrick Moynihan Lis Lowe👩🏼‍🔬 Sam Jenn Ross #microbiology #glycobiology nature.com/articles/s4146… (this time with the correct image...)

Delighted to see our trick for getting co-crystals with IgG Fc being put to good use! Checkout "Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody" nature.com/articles/s4146… and our paper describing the trick: nature.com/articles/s4146…

A very delayed post, but happy to say our highly-collaborative OGT paper recently landed at PNAS! Here we identify a new binding site within the intervening domain of OGT. Wonderful as always working with Matt Alteen LaboratoryChemicalGlycobiology ProfG #glycotime pnas.org/doi/10.1073/pn…

Super excited to offer South Coast Biosciences DTP project w/ Max Crispin and Andy Pickford. This project will investigate links between carbohydrate-processing enzymes and brain development. Please share with any students looking for PhD opportunities #glycotime southcoastbiosciencesdtp.ac.uk/project/identi…

New PhD opportunity available in the Lovering Lab! Great opportunity to explore the wonderful world of Bdellovibrio. Plus, Andy is a brilliant scientist (and supervisor).

Glad to finally see this work in print. rdcu.be/dNcz9 Aaron really smashed it on this one. This happens to be published the same day he graduated. #teammannan #glycotime. Look out for some follow up work as this paper probably raises more questions than it answers.

A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V | Journal of the American Chemical Society @DrGlycoBen The Francis Crick Institute Imperial Chemistry #Bioorthogonal #Acetylglucosaminetransferase #Tools #Chemoenzymatic pubs.acs.org/doi/10.1021/ja…