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Here's what we know already for Aquablation vs HOLEP Juan Justo Quintas recent paper at 6 MONTHS: Aqua = 0% leakage. 95% ejn preserved HOLEP = 4% leakage. 11% ejn preserved #WATER3 to provide early recovery at 1 & 3 months? % of men needing pelvic physio?

Congratulations to Exact Imaging and our colleague Moises Socarras for the publication of the OPTIMUM trial in JAMA demonstrating non-inferiority of microultrasound vs MRI for prostate cancer diagnosis ICUA

Trifecta definition comparison but without a clear/consistent or reasonable definition of failure at 1 year and no PRO assessment of erectile function but how many potent per Tx with a median age of 74 years… 🫤

#EAU25 in my opinion focal therapy results should be presented with biopsy results on a per patient level not in-field. Patients are treated not just parts of prostates. Continence should be simple pad use, not 0-1 pads. If a man is buying pads a year after Tx are they continent?

John Rewcastle, PhD Exactly what I think. Calling "continence" 0-1 pads is absolute bullshit. Continence means no leaks ever, no pads

Imperial Prostate Deepika Reddy Hashim U. Ahmed Focal Therapy Society Traditional risk classification strategies don’t seem to work for surveillance, radiation or surgery either… they all need to be revisited and updated. At the very least they need to include mpMRI guided biopsy.

Joseph Norris Failed may not be the right word in as much as ‘clinically significant’ is no longer the right word (‘actionable disease’ is better). We don’t say AS failed at progression but certainly the man is on the path to more Tx harm. Any ideas on a more appropriate term?

Nikolaos Liakos A level of reasonableness needs to be applied - hard to define though. I agree that a safety pad for M1 should be considered part of recovery. Beyond that I can’t get behind - much of the Retizus sparing literature considers a man using a safety pad at M12 continent 🙄

Prospective multinational multistudy data from 528 patients showing safety, efficacy, durability and reproducibility of #Aquablation for #LUTS due to #BPH for small, medium and large prostates #EAU25 Dean Elterman Dr_KevinZorn

Adios Madrid and #EAU25. BTW you know you’re in Spain when the directions to the train station involve ‘turn left at the ham museum’

Gustavo OncoAlert It frustrates me that RT studies don’t include biopsy in a transperineal biopsy era with the compelling correlation of any Bx+ after Radiation with Phoenix failure (3X), metastasis (3X) and PCa specific death (5X) pubmed.ncbi.nlm.nih.gov/33558660/

Professor Jonas Hugosson : ‘Screening is a form of surveillance’. Never thought about it like this before but agree it is one end of the spectrum with active surveillance on the other side. #ipftsmasterclass25

Totally agree with Kara Watts that the DRE is dead but good luck convincing the GPs of this….

Concerning learning from #IPFTSmasterclass: ~65k US men have Phoenix failure after PCa RT annually making radio recurrent prostate cancer the 4th most commonly diagnosed US cancer in men! Now, contextualize this with the fact that Phoenix is a surrogate for metastatic disease.

Encouraging results presented for Aquablation in men with prostate cancer #AUA25. Five-year outcomes are from men on active surveillance who had BPH Aquablation for LUTS. Short term data from 2 prospective cancer Aquablation trials. Complete story here: ir.procept-biorobotics.com/news-events/ev…

Inderbir Gill of USC Urology presented the game changing design of WATER IV PCa at #AUA25: a randomized comparison of whole gland Aquablation and prostatectomy. The outcome could fundamentally change the management of #prostatecancer for many men

JAMA Oncology IMHO this would be more meaningful / relevant if the analysis was based on GG at biopsy not final path. Even better would be to include upgrade rate (Bx to final) evolution over the years.

Alexander Kenigsberg Focal Therapy Society Focal One Profound Medical I have immense respect for this effort and congratulate Eduard. Unfortunately, interpretation is precluded by (1) randomization broken by crossover (25% in RP arm) and (2) asymmetric primary endpoints. Simply can’t have different primary endpoints for the two arms.

First human bladder transplant performed at UCLA performed with USC Urology’s Dr. Inderbir Gill ✌️#bladdertransplant #uclaurology #uscurology #urosome uclahealth.org/news/release/f…

Talking about Biden’s #prostatecancer in terms of Gleason scores rather than International Society of Urological Pathology grade groups is a step backwards and an unfortunate missed opportunity for patient education.