#rsjc results cont

#rsjc discussion · Authors concluded that overall20mg/kg od x 2mos met the prespecified criteria for non-inferiority for safety, but had signif lower completion. In 30 mg/kg grp, safety &completion signif worse c/w the 2 mos 20 mg/kg group &4 mon 10 mg/kg grp.

#rsjc Discussn: Compared to previous literature, consistent that high doses of 30-35 mg/kg daily of rifampicin might increase the risk of hepatotoxicity

#rsjc limitations

#rsjc critical appraisal By Rigya Arya

#rsjc next we will be moving on to Does Rheumatoid Arthritis Increase the Risk of COPD? Rheumatology Pearls Rheum Journal Club American College of Rheumatology journal.chestnet.org/article/S0012-…

#rsjc Study Objective Objective: Does RA increase the risk of developing COPD? Is there a difference between seropositive and seronegative RA in the risk of COPD?

#rsjc Study Design · Korean National Health Insurance Database utilized to review clinic data · Retrospective Cohort · Incl pt dx w/RA 2010 - 2017 · 46,030 pts with RA & 230,150 matched ctrl · Pts monitored until Dec2019

#rsjc inclusn/exclusn criteria

#rsjc primary outcome: Diagnosis of COPD that occurred >1 yr after date of RA dx (index date) New COPD dx defined as : (1) medical insurance claims for ICD-10 codes of COPD /emphysema >3 times/yr (2) medical insurance claims of hosp w/aforementioned codes as main dx code

#rsjc results

#rsjc critical appraisal by Dr M Basuita

Any thoughts on this from our #rheumatology Rheum Journal Club colleagues? Does Rheumatoid Arthritis Increase the Risk of COPD? journal.chestnet.org/article/S0012-…

Thanks for joining #rsjc! Thanks to the presenters (Dr Basuita, Rigya Arya), organizer Julie Semenchuk, moderator Matthew Stanbrook, tweets Anju Anand and PD @jmo__ and of course all the participants- enjoy summer!