SIRT1, a target of resv, linked to mood disorders May be due to SIRT1's role in the body clock. Resveratrol alter mood? http://bit.ly/d6yzgg

Review out on SIRT1 activation by polyphenols such as resveratrol. http://bit.ly/9ZjabI

Resveratrol blocks fat cell formation, effect requires SIRT1 gene. Possible implications for treating obesity. http://bit.ly/az81XY

Resveratrol and SIRT1 shown to increase protective enzyme in blood vessels (eNOS). SIRT1 requires AMPK (ie metformin target) to prime eNOS.

Requirement of AMPK for SIRT1 to deacetylate eNOS can explain why resveratrol has reduced effects in mice lacking AMPK.

Resveratrol and SIRT1 (by inhibiting PARP-1) reduce lung damage caused by cigarette smoke. http://bit.ly/dnvnHq

Six weeks of high-intensity interval training increases SIRT1 activity in human skeletal muscle by 58%. Appl Physiol Nutr Metab 35:350

Resveratrol protects human retinal cells from damage from cigarette smoke toxins. J Ocul Pharmacol Ther. 2010 Jun;26(3):231-6.

Resveratrol (12.5 mg/kg) reduced the growth of melanoma in mice and prolonged survival by 32%. Impressive finding. J Cell Biochem. 2010

In mouse model of Huntington's, SRT501 (resvtrl) controlled energy imbalances, no effect on brain atrophy or survival. Exp Neurol. 2010

"Old mice [with more SIRT1, a resv target] have better health during aging. [Less] diabetes, osteoporosis, cancer." http://bit.ly/bPqtNW

New study: Resveratrol had no benefit in mouse model of ALS (Lou Gehrig's disease). http://bit.ly/a17jNr

Anti-cancer mechanism: Resveratrol prevents cells from silencing the BRCA1 breast cancer suppressor gene. http://bit.ly/b7vXmj

Trace amounts (nM) resv block NO-mediated catecholamine release, explantn for cardiprotective effects of wine intake.http://bit.ly/b4mO21

Sirtris publishes Pfizer's conclusions r wrong: mechanism for direct SIRT1 activation by resveratrol + drug candidates. http://bit.ly/bPTH3W

Aging decreases SIRT1 activity in wake-active neurons. May explain "impaired wakefulness" in elderly. http://1.usa.gov/g9Et2X

Intermittent eating as good as caloric restriction at reducing weight loss but CR better for maintaining lean mass. http://1.usa.gov/dFtffw

Removal of cell signaling G protein RASGRF1 extends mouse lifespan 20%. Blood measures match calorie restriction. http://1.usa.gov/hteem3

Resveratrol may negate the cytotoxic effects of proteasome inhibitors on leukemic cells. http://1.usa.gov/fFmdPl

Resveratrol & spermidine extend life in simple organisms. They affect the acetylation of proteins in similar fashion http://1.usa.gov/hExDNU