Optimist: The glass is 1/2 full Pessimist: The glass is 1/2 empty Engineer: The glass is twice as big as it needs to be Excel: The glass is January 2nd

Tobacco smoking and other exposures shut off cancer-fighting genes: Nina Nina Adler wrote a beautiful summary of our recent cancer genomics study. Some mutational processes are like broken printers that insert punctuation marks in protein-coding sentences doi.org/10.25250/thesc…

Excited to present our new preprint: Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes: biorxiv.org/content/10.110…. TOP2B ChIP to analyse non-coding drivers & mutational processes in 6k cancer genomes +in vivo validation of RMRP locus as a new driver.

New preprint: Combinations of genomic alterations and immune microenvironmental features associate with patient survival in multiple cancer types. biorxiv.org/content/10.110… + the method PACIFIC for finding clinically-correlated pairs of molecular features in multi-omics datasets.

Read our latest #research on glioblastoma origins and growth, injury-reprogramming to neural crest-like identity, led by Akram Hamed from my lab, with Lincoln Stein,MarioniLab,Benjamin Simons, published with Springer Nature in @nature, rdcu.be/d5n7I