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Our lab's Holiday Card tradition (adopted from the sabeti_lab) continues into year 2. Can you spot the lab members and scientific jokes hidden in our growing laboratory? Check out  reilly-lab.com/newyears-card-… for a key to all the science puns! Happy New Year from the Reilly Lab!

Exciting news from the department!

I am delighted to see our work studying GWAS and eQTL causal alleles out in the wild. We learned several insights into how non-coding variation impart their effects. See Layla and Jacob’s tweetorial below for details.

Our absolutely amazing postdoc Stephen Rong wrote a great review on MPRA, CRISPR, and machine-learning approaches to understanding the function of non-coding regulatory changes in human evolution. Take a look!

Awesome to be part of this effort, especially with Thanh Thanh L. Nguyen making a heroic push to go from somatic variants to function effects in just a few months!

Using #AI, a Broad/The Jackson Laboratory /Yale School of Medicine team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. broad.io/CRE-AI Steve Reilly

🔥🔥🔥 new paper out from Steven Reilly Steve Reilly together with Ryan Tewhey Ryan Tewhey led by Sager Gosai Sager Gosai + Rodrigo Castro Rodrigo I Castro Synthetic cis-regulatory elements (CREs) that drive cell-type-specific gene expression 🧬🤯 nature.com/articles/s4158…

Here's an amazing explanation of our new paper from one of the brilliant minds behind it, Rodrigo I Castro! Check it out.

See John Butts's Poster #6047 Want to run an MPRA faster, cheaper, across cell types? We developed an accurate model of MPRA activity and highlight findings from assaying 100M+ variant effect predictions for fine-mapped variants, gnomAD, ClinVar, COSMIC, and more!