Awesome defense Reem Elorbany! Heart cells are pumping so fast after hearing all that exciting research!

Thanks, cardboard mentor! One degree down 😎

Single-cell seq with multiple differentiation trajectories? Pseudotime inference? Dynamic QTLs with lineage specificity? Throwbacks to the good old days of bulk sequencing (i.e. 2 years ago)?? Yes, folks, we’ve got it all! Check out our preprint:

Cool single cell analysis across multiple time points from iPSCs to cardiomyocytes from Reem Elorbany Alexis Battle and team

So excited to share our recent work! It's a full day late, so I'm sure most of the scientific community has already dug deep into the paper 😂, but for those that haven't yet, bite-sized version below! (🧵1/n)

scRNAseq of iPSCs from 19 cell lines into cardiomyocytes at 7 time points. Reem Elorbany Josh Popp and team show both lineage specificity and pseudotime improve power for detecting dynamic eQTLs.biorxiv.org/content/10.110…

For the past couple of years we have been working on a new in vitro model for dynamic eQTL mapping. Our goal was to develop a model that will allow us to map eQTLs that are only active early in development --

For the past few years I've been working to characterize embryoid bodies as a system for the discovery of dynamic eQTLs. The pilot study is available as a preprint now, and we're really excited about the potential future directions with this model!

Excited to share our latest paper on single-cell, lineage-specific eQTLs in differentiating cardiomyocytes. Led by Josh Popp and Reem Elorbany, collab with Yoav Gilad. Online early @plosgenetics: journals.plos.org/plosgenetics/a…

So excited to share my first paper, out in final form at PLOS Genetics! Co-led w the amazing Reem Elorbany, we used single-cell RNA-seq to find hundreds of dynamic eQTLs in differentiating cardiomyocytes (1/3) journals.plos.org/plosgenetics/a…

Cells don't differentiate at the same speed; they don't even head down the same path. W single cell data we pinned down & compared very homogeneous groups of cells, better than we could in bulk ➡️ way more genetic effects, many of em specific to one path or the other! (2/3)

Icing on the cake is that after characterizing these paths & cell types, we can go back and take a closer look at the bulk data, revealing hundreds of cell type-specific eQTLs in cell types we previously weren't even sure existed. (3/3)

Our paper on embryoid bodies as a new in vitro model to study human biology is now published: elifesciences.org/articles/71361

How can variant-gene associations change over time? Elorbany & Popp et al analyze gene expression data from stem cells differentiating to cardiomyocytes 🔎: doi.org/10.1371/journa… Reem Elorbany Josh Popp Ben Strober Guanghao Qi Yoav Gilad Alexis Battle #genetics #stemcells

My sister's new documentary is premiering at Tribeca! Super proud of her, and very excited to see this one.

Very excited to share my thesis work Science Immunology showing the epigenetic and transcriptional mechanisms that govern tolerance induction for auto-reactive B cells during development. @UChicagoImmuno UChicago Pritzker School of Medicine BlackInImmuno science.org/doi/10.1126/sc…

My sister @heba_elorbany’s documentary is on PBS, and free to watch for the next month! It explores the last few decades of American history through the lens of a variety of Muslim American experiences. Check it out and let me know what you think! pbs.org/pov/films/acto…

Very excited to join #StanfordTIP in a few months!! AND I'll be going with my superstar classmates Molly Imgruet and Christine McIntosh Kambe, MD, PhD... always <3 Chicago but we're California girls now ! 😎 StanfordMedRes