Congratulations to CIBSS member Peter Walentek Peter Walentek for being awarded a DFG public | @[email protected] #Heisenberg Fellowship for his research on mucociliary epithelia!👏 ➡️cibss.uni-freiburg.de/news/walentek-…

Super happy that our#MechanoFate🐸 project received #ERCCoG funding! Huge thanks to my incredible team, friends, and colleagues for their invaluable help, as well as to the reviewers, and the panel. Exciting time ahead! UCPH Healthscience @UCPH_reNEW reNEW

🚨 The lab of Asifa Akhtar uncovered in @nature a mechanism that safeguards the biallelic expression of haploinsufficient genes. The epigenetic regulator MSL2 acts as an “anti-monoallelic” factor that maintains biallelic gene dosage. This discovery not only reveals a

Ever considered that the loss of your favorite epigenetic factor might impact gene expression in an allele-specific manner? Our new study shows allele-specific gene regulation by the chromatin regulator MSL2.nature.com/articles/s4158…

Very curious if anyone guessed this 😁 Our 2023 Method of the Year is methods for modeling development (aka embryoids)!!!! Some amazing things happening in this space enabling our understanding of the earliest stages of embryogenesis and beyond. Please enjoy the issue!

The modularity/robustness of #gastruloids to explore rltnshp between #metabolism/#CellFate; 3 #preprints teamstembryo jesse veenvliet @jesseveenvliet.bsky.social: shorturl.at/jptDE Kristina Stapornwongkul Trivedi Lab shorturl.at/sxBFL earlier from Chaitanya Dingare Ben Steventon shorturl.at/aozD4

Two back-to-back manuscripts on metabolic control of germ layers using gastruloids/stembryos tinyurl.com/576pzzy2 by Kristina Stapornwongkul in Trivedi Lab & Miki Ebisuya and tinyurl.com/43e6x7su in jesse veenvliet @jesseveenvliet.bsky.social! An exciting time for metabolism and in vitro models of development!

📢 Marc Timmers of Universitätsklinikum Freiburg will speak at our #DahlemColloquium! 📜 Basal transcription factor TFIID in neurodevelopment and neurodegeneration 📆 11. DEC, 11:00 AM (CET) 📍 MPIMG , Berlin 🔗 molgen.mpg.de/events/36185/3…

"....Mouse embryos in diapause are sustained by using lipids as primary energy...." source nature.com/articles/s4155… by Aydan Bulut-Karslioglu and colleagues. also another cool work by Aydan Bulut-Karslioglu and colleagues Nicolas Rivron Niakan Lab using this to control dev timing in 🕺🏃

We provide further evidence for the downregulation of NOGGIN by pSMAD, as predicted by our simulations, and detail the early antiphasic behavior of GDF5 and pSMAD that result from a self-organizing Turing system that drives joint initiation in developing digits of amniotes... 2/3

TBX3 is essential to establish the posterior boundary of anterior genes and up-regulate posterior genes with HAND2 during onset of limb bud development dlvr.it/T2FCW2

Happy to share Tanja‘s new preprint: looking@transcription from quite a different angle: basal TFIID, IDRs and splicing.

Please RT: Job opportunity! The Faculty of Medicine at the University of Freiburg, Germany, invites applications for a Full Professorship for Biochemistry and Molecular Biology. Universität Freiburg Uniklinik Freiburg med.uni-freiburg.de/en/administrat…

WRT the recent interest in TbxT, aka #Brachyury, & all kind of tails, nice historical perspective on this most iconic gene in the history of #DevBio shorturl.at/lEK57. Below, heroes of Brachyury (Fig.2 in ref ) + B. Herrmann, who cloned the gene &, of course, the T/+ mouse

I am very proud of Yasmine from the lab for winning a poster prize at the #GfE2024 organized by the German and Dutch societies for developmental biology for her work on Hes1 dynamics in the embryonic tail. Congratulations!

Happy to share latest work from the Lab by lead author Chiara Schröder, out in DevCell: global enhancer remodeling giving competence for mesoderm/endoderm differentiation by co-workers EOMES and SWI/SNF. Transcription comes later! So, EOMES is not a TF, but a chromatin regulator!

cell.com/developmental-…

BTW, you now also find us here: @gastrulomicslab.bsky.social

Finally out in print! Check out our study on multiparameter imaging to reveal cancer cell state-dependent crosstalk with stroma that determines patient outcome 👇

We are looking for a new colleague :) Please, spread the word!