New online! Reactivation of retrotransposable elements is associated with environmental stress and ageing bit.ly/4497Z5r

Thrilled to see the 2025 Yale Kavli Postdoc Fellows announced! Huge congrats to Zhen Lei and Madeleine Junkins—your work is inspiring, and we’re proud to support the institute that helps make it possible! #KavliNeuro #KavliInstitute

Honored to receive the 2025 Kavli Postdoc Fellowship! Many thanks to my mentors Junjie Guo 郭俊傑 and David Breslow lab for their incredible support, and to the Kavli Institute Yale Kavli Institute for Neuroscience for supporting our interdisciplinary efforts. Excited for what lies ahead!💪

Nature research paper: Deciphering disordered regions controlling mRNA decay in high-throughput go.nature.com/3RtYI0x

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…

Can blocking “jumping genes” treat diseases and aging? Learn more: scim.ag/4iPW2p7 News from Science

The landscape of RNA isoforms in human cortex is revealed by deep long-read RNA sequencing go.nature.com/3V8qEtq rdcu.be/ekKw6

So 🥳excited🎉 to publicly announce what we’ve been working on for over two years, 🔥Spearhead Bio🔥, which comes out of Danforth Center and my lab’s love of transposable elements!! danforthcenter.org/news/danforth-…

Repeat-element RNAs integrate a neuronal growth circuit: Cell cell.com/cell/fulltext/…

How rogue jumping genes can spur Alzheimer’s, ALS: knowablemagazine.org/content/articl…

.nature reports on how scientists have found a way to jam the inner workings of biomolecular condensates. A synthetic ‘killswitch’ protein gives researchers a previously unattainable handle on difficult-to-study cellular structures. go.nature.com/3FXt0Xk

CRISPR just scored its biggest win yet against Huntington's. The secret? A delivery system called RIDE that sneaks into neurons, makes its edit, then vanishes in 72 hours. Here's what happened 🧵👇

Target ALS is funding a bold new wave of therapies aimed at TDP-43 pathology early in the disease process, with the potential to delay or even prevent symptoms. Read how we're taking aim at TDP-43: bit.ly/45ZZDxU #ALS #TDP43 #Neuroscience #EveryoneLives

Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes: …arneurodegeneration.biomedcentral.com/articles/10.11…

Join us to present your cutting-edge research, connect with yale neuroscientists. Apply by September 7!

Excited to see the work by Yale Interdepartmental Neuroscience Program students Suzhou Yang Denethi Wijegunawardana w/ collabs Yale Neuroscience iPSC core Joao Pereira Tanina Arab and Mayo Clinic Neuro Tania Gendron Udit Sheth on #C9orf72 #ALS & #FTD finally out in Nature Neuroscience! Wu Tsai Institute | Yale University Yale Kavli Institute for Neuroscience nature.com/articles/s4159…

Most genetic reports label variants as ✅ “pathogenic” or ❌ “benign.” But what patients really want to know is: what are my chances of getting the disease? 🚨 In our new Science study, we used AI + 1.3M patient records to better answer that…

Lewy body dementia promotion by air pollutants | Science science.org/doi/10.1126/sc…

A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain dlvr.it/TMyyhx

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below 👇 biorxiv.org/content/10.110… (1/11)