Join Ed down at Hopkins!

The SecA motor generates mechanical force during protein translocation: nature.com/articles/s4146…

New work from our next-door neighbors Salic Lab ! Congratulations @KP_BioMed and Brad Wierbowski! cell.com/developmental-…

Congrats to our former PhD student, Marco Catipovic (now at Green Lab), on his paper in EMBO Reports: "Protease protection assays show polypeptide movement into the SecY channel by power strokes of the SecA ATPase" #ATPase #translocation embopress.org/doi/abs/10.152…

New work from Salic Lab on Hh co-receptors. Wonderful PhD work from Brad. Congratulations!

Structure of the Human Signal Peptidase Complex Reveals the Determinants for Signal Peptide Cleavage biorxiv.org/cgi/content/sh… #bioRxiv

#CryoEM structure of the post‐translational Sec #translocon with substrate bound and X-ray/HDX of the Sec62 subunit. ➡️ The EMBO Journal paper online now! Congrats to @tw_weng, Jingdong Cheng, BangeBalcony and everyone involved! 🎉👏 embopress.org/doi/abs/10.152…

Five signaling pathways play an inordinately important role in normal development: Wnt, Hedgehog, RTK, Notch and BMP/TGFß. Of course the Wnt pathway is closest to my heart but Hedgehog signaling is a close second. 40 years of study and it still has surprises 1/7

Want to know what will happen if a membrane protein is too good at generating curvature? Check our new paper nature.com/articles/s4146…

Check out our new review on protein translocation through a distorted lipid bilayer. authors.elsevier.com/c/1cVIr3QxxSjU…

Check out our new preprint on Making the nanobody Big again for Cryo-EM, spearheaded by Xudong Wu (will start his own lab at Westlake University soon) in the lab.👉 biorxiv.org/content/10.110…

Excited to share our study on the mechanisms underlying selective autophagy of lipid droplets. We showed that Troyer syndrome protein spartin is a key to this! A wonderful collaboration with Joongkyu Park and Talley Lambert. Amazing support:Damon Runyon Cancer Research Foundation biorxiv.org/content/10.110…

Legobodies are online now, with full sequences available! Have fun!👉pnas.org/content/118/41…

Check out our new preprint on the translocation mechanism of the holy-grail Cdc48 ATPase. Congrats to Zhejian Ji and Hao Li, as well as to our wonderful collaborators the Engen lab John R. Engen , the Marto lab, and Gygi Lab !

We are thrilled to share our new work published in Nature today reporting a long-sought peroxisomal retrotranslocation channel formed by a ubiquitin ligase complex. Phenomenal work by our postdocs Peiqiang Feng, Xudong Wu and collaborators. nature.com/articles/s4158…

Mystery unveiled! Peroxisomal protein import resembles that of nuclear pore! Congratulations to Yuan and Mike for their joint effort! Thanks to HHMI for their continuous support on this project! …science-org.ezp-prod1.hul.harvard.edu/doi/10.1126/sc…

Excited to share our latest work led by our postdoc Dan Zhao! We uncovered how the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase (Pdi1) initiates ERAD. A long-sought ERAD reductase is finally discovered! nature.com/articles/s4159… Huge congratulations!

Read our latest #research "Import mechanism of peroxisomal proteins with an N-terminal signal sequence", published with Springer Nature in Nature Cell Biology rdcu.be/elkQ3