We are one mutation away from human-to-human transmission of H5N1 (bird flu). 🧵1/9

Researchers used AlphaFold alone (no wet-lab experiments; no cryo-EM etc.) to build a structural model and predict how a huge complex in cells, made of 17 proteins, spans across the bacterial cell envelope to transduce force for motility. Can anyone tell me if this is a first?

New preprint 🚨: with Mariusz Madej we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. biorxiv.org/content/10.110… #cryoEM

The gut-brain axis has therapeutic implications for neurodegenerative disorders. 🧵1/9

Congrats Simon! I enjoyed our time together while starting protein design at DeepMind. Excited to see what you build. Consider joining latent labs if you're interested in ML and bio!

I was happy to write a nature News and Views on the amazing discoveries by Brian Liau & Ning Zheng lab on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Nature News & Views nature.com/articles/d4158…

Jupiter and Mars dance around the sun, creating an amazing pattern.

Synthetic evolution of Saccharomyces cerevisiae for biomanufacturing: Approaches and applications onlinelibrary.wiley.com/doi/10.1002/ml…

The John Briggs, alongside teams from CIID_Heidelberg and YaleMicroPath, uncover the elusive role of the #HIV-1 component SP2. Detailed 3D views of virus particles by #cryoEM show how SP2 helps the virus matrix to mature. ❕Read the paper nature: nature.com/articles/s4158…

What's better than 1 deep mutational scanning (DMS) library? 2! In a new pre-print Brittney Thornton and Rachel F Weissman et al. map the mutational landscape of ISDra2 TnpB protein and reRNA and leverage these datasets to engineer highly active variants (1/9)

Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out By Janet Iwasa

This is jaw dropping level stuff!

I am hiring a postdoc in AI-development for protein binder design for my lab at Stockholms universitet and SciLifeLab. The environment is fantastic with many opportunities for collaboration and development of independent research directions. Apply here: su.varbi.com/en/what:job/jo…

Now an AI (GelGenie) can analyze our ugly electrophoresis bands. Are you feeling the AGI? 🦀 GelGenie: an AI-powered framework for gel electrophoresis image analysis nature.com/articles/s4146…

Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses. biorxiv.org/content/10.110… This #cryoEM study was led by Ruben Hulswit, with key contributions from an amazing team.

New story - the structure of the Vault cap at 2.3 Å! Fantastic work by Huan Li (Huan Li). For more details, read the preprint, or check out my thread at the other place! 😊🟦☁️ biorxiv.org/content/10.110…

𝐀 𝐫𝐞𝐦𝐢𝐧𝐝𝐞𝐫 𝐭𝐡𝐚𝐭 𝐩𝐫𝐨𝐭𝐞𝐢𝐧𝐬 𝐚𝐫𝐞 𝐡𝐢𝐠𝐡𝐥𝐲 𝐝𝐲𝐧𝐚𝐦𝐢𝐜 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞𝐬. Static protein structures are useful, as long as we remember that they capture only one conformation of a protein. 1/2

Architecture of the photosynthetic oxygen evolving center in dark-adapted photosystem II Find out more at tinyurl.com/3ptwcw4v

In a single E. coli, about 25 percent of all proteins use metals (like zinc, iron, copper, magnesium, etc) to do their chemistries. And yet, incredibly, fewer than ONE FREE METAL ION is present per cell on average. There are, in other words, basically no loose metal ions

It’s a parlay