I am currently on the job market and excited to be at #AIChE2022 (see⬇️) The (future) Shrinivas lab will work to engineer biomolecular condensates in living cells as functional multiphase matter with applications to genome/synth. biology, human health, and materials design.(1/3)

Hello San Diego and #bps23! Come check out what the brangwynnelab is up to these days: My talk is today in IDP symposium, Ushnish Rana presents on Tuesday, and Jessica Zhao, Chang and I also give posters on Wednesday.

So excited to share our work: We combined expts and sims to figure out how oligomerization can drive condensate immiscibility! Surprisingly which IDR is oligomerized matters i.e. asymmetric! Only possible thanks to our interdisciplinary super team, glad to have been a part of it!

I'm proud to introduce you to the IDRome 👋🍝 We performed simulations of 29,998 IDRs from the human proteome and analysed sequence-ensemble-function relationships. For a quick intro watch 🎞️👇 and then read: biorxiv.org/content/10.110…

📷Research Scientist Igor Siwanowicz’s captivating micrographs of the natural world will now grace the envelopes of millions of letters sent through the US mail, with 5 of Siwanowicz’s images featured on U.S. Postal Service #LifeMagnifiedStamps released Aug. 10.📫1/7 🔗janelia.org/news/janelia-s…

Great to have this paper finally out! Congrats to all of our amazing collaborators who helped make this happen, including the exciting new additional data added since biorxiv version was posted. The nucleolus gets more and more interesting by the day... (and stay tuned :)

Excited to have my PhD work in the Bazant group at MIT, in collaboration with Braatz group at MIT, Chueh group at Stanford, and Brian Storey at Toyota research institute, out on nature and featured on MIT homepage! (1/n) web.mit.edu/spotlight/lith…

My first postdoc work supported by Omenn-Darling Bioengineering Institute is published at Physical Review Letters coincidentally at the same time studying bacteria chemotaxis. How did I go from batteries to bacteria??? In fact, they have a lot in common in a theorist's oversimplified eyes. (1/n)

Excited about this beautiful manuscript from Mack Mack Walls & Kevin Xu, 2 students in our & Jose L. Avalos. Mapping out design parameters of synthetic condensates for metabolic flux & other applications. Organelle engineering is heating up! biorxiv.org/content/10.110…

Very cool work dissecting the role of condensate interfaces in driving aggregate nucleation. Further adding to recent findings connecting interfaces and aggregates. Condensate interfaces proving to be a lot more interesting than expected!!

Our article is now live at Nature Cell Biology! representing a fantastic collaboration with D. Allan Drummond and squire lab. We demonstrated reversible storage of stress-induced orphan ribosomal proteins within chaperone-stirred liquid condensates. Dive in nature.com/articles/s4155…

I am excited to share our whole nucleus study that provides structural and dynamic modeling of the diploid genome (100kb resolution), lamina, speckles, and nucleoli. We have consolidated our modeling effort into an open-source GPU-enabled software. biorxiv.org/content/10.110…

Thrilled to be a part of #AIChE2023, I will present my Future Lab vision at the Meet the Faculty Candidates Poster Session #292, Nov 5, 2023. Please come say hi! New polymer chemistry for Condensate engineering, Bacterial adhesion, and Novel Polymer Therapeutics.

Physiology: Modern Cell Biology Using Microscopic, Biochemical, & Computational Approaches 🔬(#MBLPhysiology) June 2 - July 21, 2024 Applications Due: Jan. 3, 2024 go.mbl.edu/Physiology

1/ My work on epigenetic memory with Leonid Mirny, Dino Osmanovic is out Science Magazine! science.org/doi/10.1126/sc… How can *stable* memory be encoded in patterns of *dynamic* epigenetic marks? We find 3D folding of genome can stabilize memory, if 3 ingredients are present...

Excited to see beautiful manuscript led by Ushnish Rana & Kevin w @iAmAllAdhesion Mack Walls Jose L. Avalos & AZP out in Nature Chemistry (...after 5 mo. copyediting :( rdcu.be/dzddw Also see related co-submission by Matthew C. Good & Jeetain Mittal rdcu.be/dxP4r

Our July issue features a focus on biomolecular phase separation that includes an editorial and a Q&A on the progress and challenges ahead in this field, along with Articles describing this phenomenon and methodology to study it in cells. Thread below!🧵 go.nature.com/4eTBRpo

Excited to share that the first paper of my PhD work in brangwynnelab is out! In this work Nature Communications, we focus on how condensates in the cell nucleus respond to mechanical deformation during cell confined migration, a process involved in cancer cell metastasis. (1/3)

Attention students and postdocs - apply for the MBL Physiology course and come find out why so many Physiology students describe the course as life-changing!!! mbl.edu/education/adva…

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity to find out - Biggest surprise was impact of encoded protein function. Fantastic work w/ Lindsay Becker Sofi Quinodoz David A Knowles (@davidaknowles.bsky.social) biorxiv.org/content/10.110…