nature.com/articles/s4158…

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor biorxiv.org/cgi/content/sh… #biorxiv_biophys

Our team has identified a non-natural retinal analogue that can activate a bistable opsin without light. Opsins are responsible for invertebrate vision and regulation of circadian rhythms in mammals. The analogues help us study light perception in animals biorxiv.org/cgi/content/sh…

Spider's opsin gaze.
Bistable paths unveil light's role.
Structural secrets.

biorxiv.org/content/10.110…

Atomically accurate de novo design of single-domain antibodies biorxiv.org/content/10.110…

Molecular insights into the atypical activation mechanism of GPR156 in maintaining auditory function
biorxiv.org/content/10.110…

This work is out today in The Journal of Physical Chemistry Letters! 🔥

doi.org/10.1021/acs.jp…

Excited to share a new preprint by Lambert lab! biorxiv.org/content/10.110…
While GPCR signaling from intracellular compartments have been well studied, it is unclear how G proteins are supplied to them. (1/n)

The story is cryoEM heavy with 160 EMDB maps and 80 models, but also has beautiful MD simulation data from the Hildebrand group Guillermo Pérez Hernández Hossein Batebi, who deserve special recognition for being amazing collaborators!

Structural insights into sphingosine 1-phosphate receptor 4 activation biorxiv.org/cgi/content/sh… #bioRxiv

There is always an exception - the first GPCR with eight transmembrane helices is an adhesion GPCR (ADGRG7).

academic.oup.com/nar/advance-ar…

Structural basis for CFTR inhibition by CFTRinh-172 | PNAS pnas.org/doi/10.1073/pn…

I am pleased to have contributed to the #cryoEM structure of the cell-free synthesized #GPCR human histamine 2 receptor in a nanodisc environment 🍾🎉
nature.com/articles/s4146…

Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains biorxiv.org/content/10.110…

I'm super proud of this one. Especially the efforts of Isabella Russell a talented PhD student at the ARC CCeMMP. Special thanks to Tracy Josephs for her MS magic! While we didn't fully adopt this orphan receptor, we made some headway into understanding it

pubs.acs.org/doi/10.1021/ac…

Binding Position Dependent Modulation of Smoothened Activity by Cyclopamine
biorxiv.org/content/10.110…

Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins
nature.com/articles/s4142…

Structural insights into CXCR4 modulation and oligomerization
biorxiv.org/content/10.110…