Ever wondered what determines RNA-DNA interactions? We set out to learn RNA:DNA:DNA base pairings from triplex-sequencing data, and the findings are out in Oxford Journals Briefings In Bioinformatics doi.org/10.1093/bib/bb… with Marcel Schulz - @[email protected] Schwalbe Lab Institute for Cardiovascular Physiology! (1/9)

Well done Tim Warwick and team! Wonderful collaboration between Institute for Cardiovascular Physiology, Marcel Schulz - @[email protected] and Schwalbe Lab. If anyone is interested in doing a #PhD or #postdoc in our lab to work on #RNA and #DNA using cutting-edge #molecular and #physiological techniques then apply now!

Excited to share our recent paper on a universal tool for RNA.DNA:DNA triplex formation that accurately predicts genome-wide RNA–DNA interactions academic.oup.com/bib/advance-ar… Tim Warwick Marcel Schulz - @[email protected] Non-coding RNA in the cardiovascular system Institute for Cardiovascular Physiology #epigenetics #rna #machinelearning #r

Checkout our new paper on RNA-DNA-DNA triplex-formation exemplified by lncRNA HIF1alpha-AS1! Exciting to learn how triplex formation emerges as fundal principle of recruitment to the DNA doi.org/10.1038/s41467… #triplex Schwalbe Lab Non-coding RNA in the cardiovascular system Institute for Cardiovascular Physiology #RNA #epigenetics

Institute for Cardiovascular Physiology ate Mexican food and drank tequila last night to celebrate three recent #lncRNA publications! pubmed.ncbi.nlm.nih.gov/36239395/ nature.com/articles/s4146… (And the 3rd will be hot off the press next week - watch this space!)

Excited to share our most recent work on PCAT19, an endothelial-specific #lncRNA, which facilitates the rapid switching between quiescence an proliferation during #regeneration and safeguards the #genome of the #endothelium. doi.org/10.1016/j.celr…

Looking forward to our SFB 1531 seminar next Tuesday! Save the date and don`t miss Laura de Rooij from CeMM talking about #endothelial cell heterogeneity! #cardiotwitter Goethe-Universität CeMM

We’ve just published another #endothelial #lncRNA paper in Basic Research in Cardiology. LINC00607 maintains ERG target gene transcription by interacting with BRG1 to mediate #angiogenesis. Fantastic work from the team! Very well done! 👏🏻 🎉 link.springer.com/article/10.100…

📢GBM and other professional societies have prepared a statement on the #WissZeitVG, see below👇 Support us and share our initiative! DGZ, @DGZ.bsky.social GDCh GfE @GfGenetik German Neuroscience Society - NWG VAAM - Vereinigung f. Allg. u. Ang. Mikrobiologie

We’re at the #DGKJahrestagung 2023 in #Mannheim today! We’ve already given some exciting talks including the presentation by Ralf Brandes for the SFB 1531 and the presentation by Frederike Boos on the #lncRNA LINC00607 in #angiogenesis.

🥳😀We are very happy that our collaborative research center on "Cardiovascular noncoding RNAs" Non-coding RNA in the cardiovascular system is extended for the next 4 years! Many thanks to DFG public | @[email protected] for allowing us to continue exploring the RNA world with our great team Goethe-Universität @LMU_Uni @MHH_life Max Planck Institute for Heart and Lung Research

🎙️What a great way to end the week! At the #JointResearchMeeting we again got great insights into cardiovascular research at the Goethe-Universität in Frankfurt. IVS Institute for Cardiovascular Physiology Stefanie Dimmeler DZHK Germany Marcel Schulz - @[email protected]

It is a great pleasure to meet all the students & fellows & faculty & scientific adivory board members of the Excellence Cluster-funded Cardiopulmonary Institute (CPI) CPI at this years retreat. Thanks to the DFG public | @[email protected] for the support!

#WeAreHiring - The CPI is offering 3 Junior Research Group Leader positions in Frankfurt to investigate aging, damage & stress responses in the cardiovascular system, and systemic interactions of the cardiovascular system. Apply: cpi-online.de/jobs-at-cpi/ IVS Stefanie Dimmeler

🎉 Today we celebrate the 10th anniversary & a decade of groundbreaking research at the European Cardiovascular Science Center Frankfurt! 🎓 50+ doctoral theses, 💰 60+ Mio € funding acquired, 📑 400+ publications! 📚💸📰 Institute of CVR IVS Institute for Cardiovascular Physiology

Poster 54: Wondering what your gene of interest does in #disease? Simonida will present how to infer functional roles of individual genes, by a novel statistical approach to exploit RNA co-expression. Institute for Cardiovascular Physiology Ralf Brandes Tim Warwick DZHK Germany #ISMBECCB2023 3/4

Happy to share our pre-print on #lncRNA recruitment of SWI/SNF to cell type-specific #enhancers. We performed several sequencing experiments to reveal the mechanism for how the highly conserved and ubiquitously expressed SWI/SNF finds its DNA targets genome-wide.

🚨 Editor's Choice Alert! 🚨 Institute for Cardiovascular Physiology finds NCoR1 limits angiogenic capacity by altering Notch signaling: buff.ly/3ITGFwp Ralf Brandes Dr Kate Weeks @vagnozzirj @monikagladka @els_cardiology

This project is the hard work of Simonida Zehr, with massive input from Marcel Schulz - @[email protected] in the frame of Non-coding RNA in the cardiovascular system (funded by DFG public | @[email protected]), with major contributions from many people from Institute for Cardiovascular Physiology (Goethe-Universität) and AstraZeneca / Cambridge University (Alessandro Bonetti + Emma Walsh)

Read the preprint @ biorxiv.org/content/10.110… and let us know how to improve RADIAnT, send feature requests, get help with problem-solving and more @ github.com/si-ze/RADIAnT