Congratulations to my mentor Uli Steidl for inspiring Marshall S. Horwitz Faculty prize 💐

Sex differences alter primitive progenitors in the C57BL/6 Tet2 knockout mouse model - Experimental Hematology Thank you Sheela Abraham for this study. I had always wondered about it and kept my experiments limited to either males or even mix. exphem.org/article/S0301-…

Cool technology! Especially for cancer and stem cell biology where every gene functions in a dosage dependent manner.

Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by Shira G-S, PhD and the whole team

#justacrazysciencethought We are born with a homogeneous mixture of fate biased HSCs, which evolve as we encounter life events.

Please check out or new paper describing a novel relationship between DNMT3A and telomeres. It truly was a team effort ! Even better when your former Peggy Goodell baymate Katherine King MDPhD publishes in Cell Stem Cell in the same issue!

NEW content online! The evolution of cancer and ageing: a history of constraint bit.ly/4oSENI3

Excited to share our latest work nature! We show that the total number of hematopoietic stem cells (HSCs) in the body is restricted, challenging the classical model that HSC numbers are determined locally by the niche and introducing a new paradigm. (1/9) nature.com/articles/s4158…

#cellfatetrade Are there agents which can lock cells into a specific transcriptional states? Won’t it be exhausting for a cell to continuously transcribe or may be this is the reason for stochastic behavior of transcription! #transcription

Honored to receive my 1st independent R01 grant from NIDDK to study how environmental exposures impact stem cells, aging, and clonal hematopoiesis. I’m now looking for a faculty position to establish my lab. Grateful to my mentor Amit Verma for the support.

Now online! Single-cell nascent transcription reveals sparse genome usage and plasticity dlvr.it/TNJwXP

Congratulations Uli 😍

Humbled to share that our latest work is now published in #CancerDiscovery Cancer Discovery : Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion doi.org/10.1158/2159-8… (1/8)

Tregs it is 😍

Here's the link to the system, try it! qedscience.com q.e.d Science