Find me at this afternoon's poster session International Society for Plasmid Biology and MGEs #ISPB2024 (or any time this week) to chat plasmid competition (poster number 41)🦠🧫

At the Danish parlement for an important conference how Denmark can contribute to actions against #AMR antibiotic resistent bacteria. We need significant investment in new solutions. I suggest #phages and phage-derived #enzymes!

The September issue is live! Cover depicting #phage responses to diverse environmental stressors. Articles on evolution in superabundant microbes, engineering agricultural #soil #microbiomes, modelling Shigella infection, cancer-associated SNPs & more! cell.com/issue/S0966-84…

Gözde S. Demirer Dipak Kathayat VIB-KU Leuven Center for Microbiology Kevin Verstrepen Rafa Pinilla-Redondo Dr. Matthew Shepherd Tiffany Taylor Sydney Miles Kat Holt Mostowy Lab

New MenT toxin-antitoxin paper for perusal! There are multiple routes to inhibit MenT toxins. Whilst phosphorylation was previously identified, the mechanism was unknown. We present a model wherein the antitoxin causes auto-phosphorylation of the toxin nature.com/articles/s4146…

A postdoctoral position is available in our lab, available immediately. Ideal candidate will have experience with membrane proteins and an interest in bacterial immunity. RTs appreciated! jobs.ac.uk/job/DJO275/res…

The final version of our paper on anti-CRISPRs "in disguise" as Cas proteins is out today in Nature! Congrats to Mark, Edith and the whole team! nature.com/articles/s4158…

Multiplexed editing of phage genomes using retrons, now published at Nature Biotechnology with lots of new bells and whistles. chloe kate crawford Santi Bhattarai-Kline Darshini Poola Karen Zhang Alex González-Delgado Matías Rojas Montero nature.com/articles/s4158…

Having a blast learning from the talks at #ISPB2024! Loved sharing our work and adding a fun twist singing “Type IV: Genie in the CRISPR Bottle” 🎤🎶

Rafa Pinilla-Redondo Looks like the ISPB website needs updating plasmidbiologysociety.org/plasmidpoems/

We have a new preprint from Ginny Giang Nguyen and Michael Michael Schelling! We show that target-strand nicking by the Cas9 HNH domain can provide #CRISPR-mediated phage protection and that nicking may be the primary Cas9 activity under some cellular conditions.

The link for the faculty position is now posted! Deadline is October 15th. Please share widely with talented scientists in your network. Come join us at UCSF! aprecruit.ucsf.edu/JPF05243

Many novel Asgard genomes, cultivated Lokiarchaeia, new phylogenetic analyses: what insights do these and other recent studies provide into the enigmatic origin of eukaryotes? In this review in nature , we discuss the latest findings and open questions: nature.com/articles/s4158…

Postdoc position in our lab to study the interplay between bacteriophages and antimicrobials in multi-drug resistant bacterial pathogens SciLifeLab Karolinska Institutet Position is supported by a KI/SciLifeLab Clinical post-doc grant ki.varbi.com/what:job/jobID…

It's exciting to see Foldseek search integrated into the AlphaFold database. Now, you can explore similar structures in PDB and AFDB50 directly on each AFDB page, along with the Foldseek clusters! It is really great for the community to have independent servers as choice.

Preprint alert 🚨! I present you the second and final manuscript on the BASEL phages! 36 new deeply characterized phages from viral groups that were so far mostly terra incognita - and all infect the E. coli K12 lab strain with easy tricks. 1/12 tinyurl.com/3xdt65f5

It is my great pleasure to present my work of the last 4 years. This work is a great example of why I love science - You often make unexpected discoveries! Thank you Marraffini Lab and all lab members for your support! (1/3)

Coming soon: A "cheatsheat" of some of the widespread anti-invader(e.g., antiviral) molecular immune processes and their sharing across the superkingdoms of Life. Each protein structure is a real rendering of an actual exemplar. The image is divide into three columns representing

The ever amazing Artyom Egorov in our group has made a new visualisation tool for comparative genomics. Makes particularly beautiful images of phages, plasmids, other MGEs or regions of prokaryotic genomes 😍 biorxiv.org/cgi/content/sh…

Registration and abstract submission for MGE AUS, a brand new meeting dedicated to mobile genetic elements are now open! -ECR and PhD student focused -Two day program to be announced soon -$150 student rego -Lots of prizes -Submissions close 29th Nov mgeaus.org