Check out our new paper on the architecture and subunit composition of the human pyruvate dehydrogenase complex which just appeared in Science Advances. Many thanks to all who contributed to this terrific collaboration! science.org/doi/10.1126/sc…

In our study in Science Advances, we reveal how ssDNA binding activates transcription factor PafBC, triggering the DNA damage response in #Mycobacteria. Read more: science.org/doi/10.1126/sc… 🔬 Cryo-EM structure 🧬 ssDNA-WYL domain interaction

Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction. 👏 Tatjana v. Rosen Rafał Zdanowicz @yasserelhadeg 🔗nature.com/articles/s4146…

All aerobic life depends on pyruvate dehydrogenase complexes ⚡ Yet their structures and assembly vary widely across species. Discover the differences: febs.onlinelibrary.wiley.com/doi/10.1002/18… #Biochemistry #Metabolism #MolecularBiology Rafał Zdanowicz Sarah Meinhold